Tramadol

Tramadol Basic information
Treatment in Particular diseases
Product Name:Tramadol
Synonyms:2-((dimethylamino)methyl)-1-(m-methoxyphenyl)-cyclohexano;cis-(+-)-cyclohexano;TRAMAL;TRANS-(+/-)-2-[(DIMETHYLAMINO)METHYL]-1-(3-METHOXYPHENYL)CYCLOHEXANOL;Cyclohexanol, 2-(dimethylamino)methyl-1-(3-methoxyphenyl)-, (1R,2R)-rel-;CG 315E;cis-Tramadol;Cyclohexanol, 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-, (1R,2R)-rel- (9CI)
CAS:27203-92-5
MF:C16H25NO2
MW:263.38
EINECS:248-319-6
Product Categories:Tramadol;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:27203-92-5.mol
Tramadol Structure
Tramadol Chemical Properties
Melting point 178-181 °C
Boiling point 406.62°C (rough estimate)
density 0.9903 (rough estimate)
refractive index 1.4909 (estimate)
storage temp. 2-8°C
pka14.47±0.40(Predicted)
form solid
color white to off-white
CAS DataBase Reference27203-92-5(CAS DataBase Reference)
NIST Chemistry ReferenceTramadol(27203-92-5)
EPA Substance Registry SystemCyclohexanol, 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-, (1R,2R)-rel- (27203-92-5)
Safety Information
Hazard Codes Xn
Risk Statements 22
RIDADR UN 2811 6.1/PG 3
WGK Germany 2
Hazardous Substances Data27203-92-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
Tramadol Usage And Synthesis
Treatment in Particular diseasesIn Osteoarthritis:
  • Tramadol with or without acetaminophen has modest analgesic effects in patients with Osteoarthritis. It may also be effective as add-on therapy in patients taking concomitant NSAIDs or COX-2 selective inhibitors. As with opioids, tramadol may be helpful for patients who cannot take NSAIDs or COX-2 selective inhibitors.
  • Tramadol should be initiated at a lower dose (100 mg/day in divided doses) and may be titrated as needed for pain control to a dose of 200 mg/ day. It is available in a combination tablet with acetaminophen and as a sustained-release tablet.
  • Opioid-like adverse effects such as nausea, vomiting, dizziness, constipation, headache, and somnolence are common.
Chemical PropertiesLight Yellow Oil
OriginatorTramadol,Gruenenthal,W. Germany,1977
UsesTramadol is thought to produce analgesia by two distinct actions. First, it has agonist activity at the MOP and KOP receptors. Tramadol itself is a prodrug, with most of its analgesia mediated by a metabolite – O-desmethyltramadol – that has a 200-fold higher affinity for the MOP receptor. I t is metabolised by cytochrome P450 (CYP2D6 and CYP3A4), and its potency is therefore affected by a patient's CYP genetics, with rapid and poor metabolisers.
S econd, it enhances the descending inhibitory systems in the spinal cord by inhibiting noradrenaline reuptake and releasing serotonin from nerve endings. It is available in immediate- and sustained-release oral preparations and for parenteral administration. I ts use is contraindicated in patients receiving monoamine oxidase inhibitors (MAOIs). Caution must also be exercised in hepatic impairment as its clearance is reduced to a much greater extent than morphine and related agents.
UsesAn Analgesic. Used in the treatment of urinary incontinence
DefinitionChEBI: (R,R)-tramadol is a 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist, a serotonin uptake inhibitor and a metabolite. It is a conjugate base of a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol.
Manufacturing Process5 g of magnesium turnings are treated while stirring with a mixture of 37.4 g of m-bromoanisole and 160 ml of absolute tetrahydrofuran at such a rate that the reaction mixture boils gently because of the heat produced by the immediately starting reaction. Thereafter, the reaction mixture is boiled under reflux while stirring until all the magnesium dissolves. The reaction mixture is cooled to 0°C to -10°C and then a mixture of 23.25 g of 2- dimethylaminomethylcyclohexanone and 45 ml of absolute tetrahydrofuran is added dropwise.
The resulting mixture is stirred for 4 hours at room temperature and then poured, while stirring slowly, into a mixture of 25 g of ammonium chloride, 50 ml of water and 50 g of ice. The layers are separated and the aqueous layer is extracted twice with 50 ml portions of ether. The organic layers are combined, dried with sodium sulfate and evaporated. The residue is distilled, and 1-(m_x0002_methoxyphenyl)-2-dimethylaminomethyl-cyclohexanol-(1), boiling point at 0.6 mm Hg 138°C to 140°C, is obtained in a yield of 78.6% of theoretical. The hydrochloride obtained from the product, e.g., by dissolving in ether and treating with dry hydrogen chloride, melts at 168°C to 175°C. By recrystallization from moist dioxan this hydrochloride is separated into isomers melting at 162°C to 163°C and 175°C to 177°C, respectively.
Brand nameTrabar.
Therapeutic FunctionAnalgesic
General DescriptionTramadol (Ultram) is an analgesic agent with multiple mechanismsof action. It is a weak μ-agonist with approximately30% of the analgesic effect antagonized by the opioid antagonistnaloxone. Used at recommended doses, it has minimaleffects on respiratory rate, heart rate, blood pressure, or GItransit times. Structurally, tramadol resembles codeine with the B, D, and E ring removed. The manufacturer states thatpatients allergic to codeine should not receive tramadol, becausethey may be at increased risk for anaphylactic reactions. Tramadol is synthesized and marketed as the racemicmixture of two (the [2S, 3S] [-] and the [2R, 3R] [+]) of thefour possible enantiomers. The (+) enantiomer is about30 times more potent than the (—) enantiomer; however,racemic tramadol shows improved tolerability.Neurotransmitter reuptake inhibition is also responsible forsome of the analgesic activity with the (—) enantiomer primarilyresponsible for norepinephrine reuptake and the (+)enantiomer responsible for inhibiting serotonin reuptake. Like codeine, tramadol is O-demethylated viaCYP2D6 to a more potent opioid agonist having 200-foldhigher affinity for the opioid receptor than the parent compound.Tramadol was initially marketed as nonaddictive, anda 3-year follow up study showed that the abuse potential isvery low, but not zero. Most abusers of tramadol have abusedopioid drugs in the past. Both enantiomers of tramadoland the major O-demethylated metabolite are proconvulsive,and tramadol should not be used in patients with a lowseizurethreshold including patients with epilepsy.
Mechanism of actionFentanyl is a μ agonist with approximately 80 times greater potency than morphine. Fentanyl has been used in combination with nitrous oxide for “ balanced” anesthesia and in combination with droperidol for “ neurolepalgesia.” The advantages of fentanyl over morphine for anesthetic procedures are its shorter duration of action (1–2 hours) and the fact that it does not cause histamine release on intravenous injection.
PharmacokineticsThe analgesic activity of tramadol is attributed to a synergistic effect caused by the opioid activity of the (+)-isomer and the neurotransmitter reuptake blocking effect of the (–)-isomer. The (+)-isomer possesses weak μ opioid agonist activity equivalent to approximately 1/3,800 that of morphine. The O-desmethyl metabolite (CYP2D6) of (±)-tramadol has improved μ opioid activity equivalent to 1/35 that of morphine. Affinity for both δ and κ receptors is improved. Despite its higher opioid potency, the contribution of O-desmethlytramedol to the overall analgesic effect has been questioned but not well studied. Individuals who lack CYP2D6 or are taking a CYP2D6 inhibitor have a reduced effect to tramadol. The fact that naloxone causes a decrease in the analgesic potency of tramadol argues strongly for an opioid component to the analgesic activity. (–)-T ramadol possesses only 1/20 the opioid activity of its (+)-isomer, but it has good activities for inhibition of norepinephrine (Ki = 0.78 μM) and serotonin (Ki = 0.99 μM) reuptake. Tramadol's neurotransmitter reuptake activity is approximately 1/20 that of imipramine, a tricyclic antidepressant agent that is used widely in pain management. Although none of the individual pharmacological activities of tramadol is impressive, they interact to give a synergistic analgesic effect that is clinically useful.
Tramadol has been used in Europe since the 1980s and was introduced to the U.S. market in 1995. The drug is nonaddicting and, thus, is not a scheduled agent. In addition, tramadol does not cause respiratory depression or constipation.
Tramadol Preparation Products And Raw materials
Raw materials3-Bromoanisole-->Magnesium-->Hydrochloric acid-->2-[(dimethylamino)methyl]cyclohexan-1-one
(+)-(1R,2R)-TRAMADOL HCL CIS-TRAMADOL HYDROCHLORIDE,TRAMADOL HYDROCHLORIDE,TRAMADOL HCL,O-DESMETHYL-CIS-TRAMADOL HCL CIS-TRAMADOL-13C, D3 HYDROCHLORIDE CIS-TRAMADOL HYDROCHLORIDE,O-DESMETHYL-CIS-TRAMADOL HCL POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE 4-Methoxyphenylacetone Methoxydiethylborane Anisole m-Anisyl alcohol (Trifluoromethoxy)benzene TRAMADOL HYDROCHLORIDE IMP. B (EP) AS HYDROCHLORIDE:[2-(3-METHOXYPHENYL)CYCLOHEX-1-ENYL]-N,N-DIMETHYLMETHANAMINE HYDROCHLORIDE p-Anisidine Tramadol Methoxyacetic acid p-Anisaldehyde TRANS-(+/-)-2-[(N-BENZYL-N-METHYL)AMINOMETHYL]-1-(3-METHOXYPHENYL)CYCLOHEXANOL, HYDROCHLORIDE (+)-CIS-TRAMADOL (S)-(+)-MANDELATE O-ETHYL TRAMADOL

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