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| | LEPTOMYCIN A Basic information |
| Product Name: | LEPTOMYCIN A | | Synonyms: | ATS 1287A, PD 118607, JildaMycin;NSC 369326;2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-;19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2-yl)-3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;19-(3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid;Antibiotic ATS-1287A;Antibiotic PD-118607;PD-118607 | | CAS: | 87081-36-5 | | MF: | C32H46O6 | | MW: | 526.7 | | EINECS: | | | Product Categories: | ADC | | Mol File: | 87081-36-5.mol |  |
| | LEPTOMYCIN A Chemical Properties |
| Fp | 9℃ | | storage temp. | -20°C | | solubility | Ethanol: Soluble; Methanol: Soluble | | form | methanol solution |
| | LEPTOMYCIN A Usage And Synthesis |
| Description | Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A inhibits Rev translocation, though less potently than leptomycin B with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours. Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent. | | Uses | Leptomycin A is an antifungal antibiotic. | | Uses | Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus. | | Definition | ChEBI: A leptomycin having all-trans double bonds and a seventh methyl substituent at position 17. |
| | LEPTOMYCIN A Preparation Products And Raw materials |
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