thonzylamine hydrochloride

thonzylamine hydrochloride Basic information
Product Name:thonzylamine hydrochloride
Synonyms:Thonzilamine hydrochloride;1,2-Ethanediamine, N-(4-methoxyphenyl)methyl-N,N-dimethyl-N-2-pyrimidinyl-, monohydrochloride;Anahist;Neohetramine hydrochloride;Resistab;N-(4-Methoxybenzyl)-N-(2-(diMethylaMino)ethyl)pyriMidin-2-aMine;thonzylamine hydrochloride;Thonzylamine HCl 98%
CAS:63-56-9
MF:C16H22N4O.ClH
MW:322.84
EINECS:2005613
Product Categories:API
Mol File:63-56-9.mol
thonzylamine hydrochloride Structure
thonzylamine hydrochloride Chemical Properties
Melting point 173-176°
Boiling point bp2.2 185-187°
density 1.2562 (rough estimate)
refractive index 1.5800 (estimate)
Stability:Stable. Incompatible with strong oxidizing agents.
EPA Substance Registry SystemThonzylamine hydrochloride (63-56-9)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36
ToxicityLD50 orally in guinea pigs: 493 mg (base)/kg (Reinhard, Seudi)
MSDS Information
thonzylamine hydrochloride Usage And Synthesis
Chemical PropertiesWhite, crystalline powder; faint odor. Very soluble in water; freely soluble in alcohol and chloroform; practically insoluble in ether and benzene; pH 5.0–6.0 (2% solution).
OriginatorNeohetramine,Warner Lambert,US,1948
UsesMedicine (antihistamine).
DefinitionChEBI: Thonzylamine hydrochloride is a member of methoxybenzenes.
Manufacturing Process54 g of 2-(p-methoxybenzyl)aminopyrimidine and 12.0 g of sodamide were suspended in 250 cc of toluene and were refluxed for 31 hours. To the thus prepared sodium salt of 2-(p-methoxybenzyl)aminopyrimidine, 28.1 g of dimethylaminoethyl chloride were added and refluxed under continuous stirring for 26 hours. After cooling, the reaction mixture was extracted with dilute hydrochloric acid at about pH 5.0, removing the product thus formed containing only very little of the unreacted 2-(p_x0002_methoxybenzyl)aminopyrimidine. This solution was then made alkaline to liberate the free base of the product, which was extracted with ether. The ether solution was evaporated and the residue vacuum distilled. The product, 2-(p-methoxybenzyl-dimethylaminoethyl)aminopyrimidine forms an oily liquid, boiling point 185°C to 187°C at 2.2 mm.
Therapeutic FunctionAntihistaminic
General DescriptionThonzylamine hydrochloride,2-[[2-(dimethylamino)-ethyl](p-methoxybenzyl)amino]pyrimidine hydrochloride, is a white crystallinepowder soluble in water (1:1), in alcohol (1:6), and in chloroform(1:4). A 2% aqueous solution has a pH of 5.5. It is similar in activity to tripelennamine but is claimed to be lesstoxic. The usual dose is 50 mg taken up to 4 times daily. Itis available in certain combination products.
General DescriptionWhite crystalline powder with a faint odor . pH: 5.1-5.7 (2 % aqueous solution).
Air & Water ReactionsWater soluble.
Reactivity Profilethonzylamine hydrochloride behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Health HazardSYMPTOMS: Symptoms of exposure to thonzylamine hydrochloride may include drowsiness, lethargy, fatigue, hypnosis, coma, vertigo, ataxia, tinnitus, blurred vision, tremors, anxiety, insomnia, excitement, hallucinations, delirium, convulsions, dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, diarrhea, central nervous system depression, gastrointestinal reactions, respiratory arrest and circulatory collapse.
Fire HazardFlash point data for thonzylamine hydrochloride are not available. thonzylamine hydrochloride is probably combustible.
thonzylamine hydrochloride Preparation Products And Raw materials
Raw materialsSodium amide-->N,N-DIMETHYLAMINOETHYL CHLORIDE-->2-(4-Methoxybenzylamino)pyridine
Sulfamethazine sodium salt thonzylamine 2-Ethanediamine,N-2-pyrimidinyl- [[(2-aminoethyl)amino]methyl]phenol N-[(4-methoxyphenyl)methyl]pyrimidin-2-amine 2-Aminopyrimidine thonzylamine hydrochloride Hetramine 4-METHOXY-N-METHYLBENZYLAMINE HYDROCHLORIDE

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