|
| | bialamicol Basic information |
| Product Name: | bialamicol | | Synonyms: | 3,3-diallyl-5,5-bis(diethylaminomethyl)biphenyl-4,4-diol;5,5'-Bis(diethylaminomethyl)-3,3'-diallyl-1,1'-biphenyl-4,4'-diol;5,5'-Diallyl-3,3'-bis[(diethylamino)methyl]-4,4'-dihydroxybiphenyl;2-(diethylaminomethyl)-4-[3-(diethylaminomethyl)-4-hydroxy-5-prop-2-enyl-phenyl]-6-prop-2-enyl-phenol;2-(diethylaminomethyl)-4-[3-(diethylaminomethyl)-4-hydroxy-5-prop-2-enylphenyl]-6-prop-2-enylphenol;2-allyl-4-[3-allyl-5-(diethylaminomethyl)-4-hydroxy-phenyl]-6-(diethylaminomethyl)phenol;bialamicol;[1,1'-Biphenyl]-4,4'-diol, 3,3'-bis[(diethylamino)methyl]-5,5'-di-2-propen-1-yl- | | CAS: | 493-75-4 | | MF: | C28H40N2O2 | | MW: | 436.63 | | EINECS: | | | Product Categories: | | | Mol File: | 493-75-4.mol |  |
| | bialamicol Chemical Properties |
| Boiling point | 506.6±45.0 °C(Predicted) | | density | 1.040±0.06 g/cm3(Predicted) | | pka | 9.67±0.50(Predicted) |
| | bialamicol Usage And Synthesis |
| Originator | Camoform HCl,Parke Davis,US,1956 | | Uses | Anti-amebic. | | Definition | ChEBI: Bialamicol is a member of hydroxybiphenyls. | | Manufacturing Process | Paraformaldehyde (7.59) (0.25mol) and 18.3 g (0.25 mol) of diethylamine are
mixed in 25 cc of alcohol and warmed until a clear solution is obtained. The solution is cooled and mixed with 26.6 g (0.10 mol) of 3,3'-diallyl-4,4'-
biphenol in 25 cc of alcohol. After standing several hours, the solution is
warmed for one hour on the steam bath, allowing the alcohol to boil off. The
residue is then taken up in ether and water, the ether layer separated and
washed with 2% sodium hydroxide solution and finally with water. The washed
ether solution is dried over solid potassium carbonate, and filtered. After
acidifying with alcoholic hydrogen chloride, the ether is distilled off and the
alcoholic residue diluted with an equal volume of acetone. The crystalline
hydrochloride is filtered off, triturated with alcohol, diluted with several
volumes of acetone, filtered and dried; MP 209°-210°C. | | Brand name | Camoform Hydrochloride
(Parke-Davis). | | Therapeutic Function | Antiamebic |
| | bialamicol Preparation Products And Raw materials |
|
