2-Butyne-1,4-diol

2-Butyne-1,4-diol Basic information
Product Name:2-Butyne-1,4-diol
Synonyms:Dihydroxydimethylacetylene;1,4-DIHYDROXY-2-BUTYNE;1,4-BUTYNEDIOL;1,2-DIHYDROXYDIMETHYLACETYLENE;2-BUTYNE-1,4-DIOL;Butynediol,99%;1,4-butynedilol(liquid);1,4-butynediol(solid)
CAS:110-65-6
MF:C4H6O2
MW:86.09
EINECS:203-788-6
Product Categories:Building Blocks;Chemical Synthesis;Internal;Organic Building Blocks;Organic Building Blocks;Electroplating;Pharmaceutical Intermediates;Acetylenes;Acetylenic Alcohols & Their Derivatives;Alkynes
Mol File:110-65-6.mol
2-Butyne-1,4-diol Structure
2-Butyne-1,4-diol Chemical Properties
Melting point 54 °C
Boiling point 238 °C(lit.)
density 1.2
vapor pressure <0.1 mm Hg ( 55 °C)
refractive index 1.4804
Fp 306 °F
storage temp. Store below +30°C.
solubility 3740g/l
form Crystalline Platelets or Flakes
pka12.72±0.10(Predicted)
color slightly brown
PH4-7.5 (100g/l, H2O, 23℃)
Water Solubility 3740 g/L (20 ºC)
BRN 1071237
Exposure limitsACGIH: TWA 0.1 ppm; STEL 0.3 ppm
OSHA: TWA 0.75 ppm; STEL 2 ppm
NIOSH: IDLH 20 ppm; TWA 0.016 ppm; Ceiling 0.1 ppm
Stability:Stable. Highly flammable solid. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong acids, strong bases.
LogP-0.73 at 25℃
CAS DataBase Reference110-65-6(CAS DataBase Reference)
NIST Chemistry Reference2-Butyne-1,4-diol(110-65-6)
EPA Substance Registry System2-Butyne-1,4-diol (110-65-6)
Safety Information
Hazard Codes T,C
Risk Statements 21-23/25-34-43-48/22
Safety Statements 25-26-36/37/39-45-46
RIDADR UN 2716 6.1/PG 3
WGK Germany 2
RTECS ES0525000
23-10
Autoignition Temperature410 °C
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29053980
Hazardous Substances Data110-65-6(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 100 mg/kg
MSDS Information
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2-Butyne-1,4-diol Usage And Synthesis
Chemical Propertiesyellow solid. Soluble in water, acidic solution, ethanol and acetone, slightly soluble in chloroform, insoluble in benzene and ether.
Uses2-Butyne-1,4-diol is used as a precursor to prepare 1,4-butanediol, 2-butene-1,4-diol and mucochloric acid. It is also used in textile additives, corrosion inhibitors, plasticizers, synthetic resins and polyurethanes. It is an important raw material of vitamin B6. Further, it is used for brightening, preserving and inhibiting nickel plating. In addition, it is used in biological studies for nematocidal activity.
ApplicationBasic brightener in nickel electroplating baths, also an important intermediate for organic synthesis; corrosion inhibitor; defoliant ; polymerization accelerator; stabilizer for chlorinated hydrocarbons; cosolvent for paint and varnish removal.
DefinitionChEBI: 2-Butyne-1,4-diol is a butynediol that is but-2-yne substituted by hydroxy groups at positions 1 and 4. It is used to produce butanedioland butenediol, in metal plating andpickling baths, and in making the carbamateherbicide Barban (Carbyne).
General Description1,4-butynediol appears as white to light-brown solid or brownish-yellow aqueous solution. Solid sinks and mixes with water. (USCG, 1999)
Air & Water ReactionsWater soluble.
Reactivity ProfilePure 2-Butyne-1,4-diol is non-explosvie. Small amounts of certain impurities-alkali hydroxides, alkaline earth hydroxides, halides-may cause explosive decomposition upon distillation. 2-Butyne-1,4-diol should not be treated with basic catalysts in the absence of a solvent at room temperature, and its stability is less with elevated temperatures. In strong acids, contamination with mercury salts can also result in violent decomposition [NFPA 491M 1991].
HazardToxic by ingestion. May explode on contamination with mercury salts, strong acids, and alkaline earth hydroxides and halides at high temperatures. May cause dermatitis.
Health Hazard2-Butyne-1,4-diol exhibits moderate to hightoxicity in test animals. It is about 10 timesmore toxic than are the saturated C4 diols.The oral LD50 value in rats is 0.125 mL/kg.It causes irritation to the skin.
Fire HazardNoncombustible solid, flash point (open cup) 152°C (305.6°F). It is stable at room temperature. But the dry compound explodes in the presence of certain heavy metal salts, such as mercuric chloride. Heating with alkaline solution may result in an explosion.
Safety ProfileA poison by ingestion. A skin sensitizer upon long or repeated contact. Moderately explosive. When heated to decomposition it emits acrid smoke and fumes and may explode. Explosive reaction with traces of alkaltes, alkali earth hydroxides, halide salts, strong acids, mercury salts + strong acids. See also ACETYLENE COMTOUNDS.
Synthesis2-butyne-1,4-diol is carried out by reaction under pressure of acetylene and an aqueous solution of formaldehyde, catalyzed by copper acetylide.
storage2-Butyne-1,4-diol can be stored in steel,aluminum, nickel, glass, epoxy, and phenolicliner containers. Rubber hose may be usedfor transfer. Avoid contact with heavy metalsalt contaminants.
Purification MethodsCrystallise the diol from EtOAc. [Beilstein 1 IV 2687.]
Solvent Red 43 2,4,7,9-Tetramethyl-5-decyne-4,7-diol 1-BUTYNE 3-Diethylaminophenol 1,4-Butanediol 1-Hydroxyethylidene-1,1-diphosphonic acid tetramethyl-2-butynedio DI(PROPYLENE GLYCOL) BUTYL ETHER 1,3-Dihydroxyacetone Triclosan 2-Butyne-1,4-diol Chrysin 1,3-Butanediol (S,S)-2,3-Butanediol 3,6-DIMETHYL-4-OCTYN-3,6-DIOL 1,4-Bis(2-hydroxyethoxy)-2-butyne 2-Butoxyethanol 2-Butoxyethyl acetate

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