4-CHLORO-1-NAPHTHOL

4-CHLORO-1-NAPHTHOL Basic information

Product Name:	4-CHLORO-1-NAPHTHOL
Synonyms:	4-chloro-1-nahphthol;4-chloro-1-naphthaleno;4-chloro-1-Naphthalenol;4-CHLORO-1-NAPHTHOL FOR DETECTION OF PEROXIDASE FOR MICROSCOPY;4-Chloro-1-naphthol [for Biochemical Research];1-Chloro-4-naphthol;1-Hydroxy-4-chloronaphthalene;NSC 44345
CAS:	604-44-4
MF:	C10H7ClO
MW:	178.62
EINECS:	210-068-5
Product Categories:	Enzyme Substrates;Peroxidase Substrates;Substrates by Enzyme;Alphabetical ListingWestern Blotting;PeroxidaseWestern Blotting;Tablets;BiochemicalsWestern Blotting;Molecular Biology;Fluorescent Enzyme Substrates for ElectrophoresisEnzyme Substrates;Peroxidase SubstratesAnalytical Reagents;Fluorescent Enzyme Substrates;Fluorescent Probes, Labels, Particles and Stains;Microscopy Reagents;Stains and Dyes;Naphthalene derivatives;Biochemistry;Enzyme;Substrates;Molecular Biology Reagents;Peroxidase;Fluorescent Enzyme Substrates for ElectrophoresisWestern Blotting;Alphabetical ListingFluorescent Probes, Labels, Particles and Stains;Detection Substrates;Powders
Mol File:	604-44-4.mol

4-CHLORO-1-NAPHTHOL Chemical Properties

Melting point	118-121 °C(lit.)
Boiling point	254.41°C (rough estimate)
density	密度
refractive index	1.4575 (estimate)
Fp	73 °C
storage temp.	-20°C
solubility	methanol: 50 mg/mL, clear, colorless to very faintly yellow
pka	9.11±0.40(Predicted)
form	tablets (~32 mg each)
color	Off-white to gray to light brown
BRN	509750
CAS DataBase Reference	604-44-4(CAS DataBase Reference)
EPA Substance Registry System	1-Naphthalenol, 4-chloro- (604-44-4)

Safety Information

Hazard Codes	Xi,T
Risk Statements	36/37/38-39/23/24/25-20/21/22
Safety Statements	26-36-45-36/37
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
F	8-9-23
TSCA	Yes
HS Code	29081990

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

4-CHLORO-1-NAPHTHOL Usage And Synthesis

Chemical Properties	Off white to tan crystals
Uses	4-Chloro-1-naphthol has been used to visualize protein bands in western blotting. It has also been used in staining polyvinylidene fluoride (PVDF) membrane by Nakane method.
Uses	Suitable for visualizing protein-peroxidase conjugates in western blotting.
Synthesis Reference(s)	Tetrahedron, 38, p. 2347, 1982 DOI: 10.1016/0040-4020(82)87012-9
General Description	4-Chloro-1-naphthol is primarily used for the detection of proteins, it gives a characteristic purple precipitate and the reactions are easily controllable. It can be used as a substitute for benzidine compounds, which are considered to be carcinogenic.
Biochem/physiol Actions	4-Chloro-1-naphthol serves as a substrate for horseradish peroxidase.
Purification Methods	Crystallise the naphthol from EtOH or CHCl3. [Beilstein 6 H 611, 6 II 582, 6 III 2933, 6 IV 4233.]

4-CHLORO-1-NAPHTHOL Preparation Products And Raw materials

Raw materials	1-Naphthalenol, 2-chloro--->2,4-DICHLORO-1-NAPHTHOL-->1-Naphthol
Preparation Products	1-NAPHTHOL-4-SULFONIC ACID SODIUM SALT-->3H-Indol-3-one, 5,7-dichloro-2-(4-chloro-1-oxo-2(1H)-naphthalenylidene)-1,2-dihydro-4,6-dimethyl--->4-chloro-1-hydroxynaphthalene-2-carbaldehyde

RARECHEM AN KA 1964 RARECHEM AN KB 1956 1-CHLORO-4-(4-FLUORO-2-NITROPHENOXY)NAPHTHALENE 2-[(4-CHLORO-1-NAPHTHYL)OXY]-1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)-1-ETHANONE 1-CHLORO-4-METHOXYNAPHTHALENE 4-CHLORO-1-NAPHTHYL 1,2,3-THIADIAZOL-5-YL ETHER ANHYDROCHLORTETRACYCLINE HYDROCHLORIDE 1-(4-CHLORO-1-HYDROXY-NAPHTHALEN-2-YL)-ETHANONE METHYL 3-((2-[(4-CHLORO-1-NAPHTHYL)OXY]ACETYL)AMINO)-2-THIOPHENECARBOXYLATE Phenyl 4-chloro-1-hydroxy-2-naphthoate 4-CHLORO-1-NAPHTHYL 2-[(PHENYLSULFONYL)ANILINO]ACETATE RARECHEM AN KB 1969 4-((4'-CHLORO-1-NAPHTHYLOXY)METHYL)PHEN& RARECHEM AN KA 1951 RARECHEM AN KA 1878 (4-CHLORO-1-NAPHTHYL)OXY]ACETIC ACID RARECHEM AN KB 1883 4-CHLORO-1-NAPHTHYL 5-METHOXY-2-PHENYL-4-PYRIMIDINYL ETHER

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