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| | Mosapride citrate Basic information |
| Product Name: | Mosapride citrate | | Synonyms: | 4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE;4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide 2-hydroxy-1,2,3-propanetricarboxylate;Gasmotin;enzamidecitrate;yl)methyl)-,2-hydroxy-1,2,3-propanetricarboxylate(1:1);4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamidecitrate;4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide;4-azanyl-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide | | CAS: | 112885-42-4 | | MF: | C27H33ClFN3O10 | | MW: | 614.02 | | EINECS: | 601-211-6 | | Product Categories: | Inhibitors;APIS;Gastroprokinetic Agent;API;TAK-370, AS-4370, Gasmotin | | Mol File: | 112885-42-4.mol |  |
| | Mosapride citrate Chemical Properties |
| Melting point | 143-145° | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | CAS DataBase Reference | 112885-42-4(CAS DataBase Reference) |
| Toxicity | LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera) |
| | Mosapride citrate Usage And Synthesis |
| Description | Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg. | | Uses | As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.
| | Uses | Mosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor. | | Biological Activity | 5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs. | | storage | room temperature (desiccate) |
| | Mosapride citrate Preparation Products And Raw materials |
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