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| | Pyrazole Basic information |
| Product Name: | Pyrazole | | Synonyms: | Pyrazole, pure, 98%;Pyrrazole;Pyrazole ,99%;PYRAZOLE, 98%, PURE;2-PyrroMonazole;Pyrazole, pure, 98% 100GR;Pyrazole, pure, 98% 25GR;PYRAZOLE FOR SYNTHESIS 25 G | | CAS: | 288-13-1 | | MF: | C3H4N2 | | MW: | 68.08 | | EINECS: | 206-017-1 | | Product Categories: | C3 to C5;Chemical Synthesis;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Pyrazole;Heterocyclic Building Blocks;Pyrazoles;Building Blocks;bc0001;288-13-1 | | Mol File: | 288-13-1.mol |  |
| | Pyrazole Chemical Properties |
| Melting point | 67-70 °C (lit.) | | Boiling point | 186-188 °C (lit.) | | density | 1.4088 (rough estimate) | | vapor pressure | 21Pa at 20℃ | | refractive index | 1.4203 | | Fp | 186-188°C | | storage temp. | Store below +30°C. | | solubility | Chloroform, Methanol | | form | Crystals or Crystalline Powder | | pka | 2.49(at 25℃) | | color | White to yellow | | Water Solubility | SOLUBLE | | Sensitive | Hygroscopic | | Merck | 14,7960 | | BRN | 103775 | | InChIKey | WTKZEGDFNFYCGP-UHFFFAOYSA-N | | LogP | 0.33 at 25℃ | | CAS DataBase Reference | 288-13-1(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-Pyrazole(288-13-1) | | EPA Substance Registry System | Pyrazole (288-13-1) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38-52-20/21/22 | | Safety Statements | 26-36/37-61-37/39-36 | | RIDADR | 2811 | | WGK Germany | 1 | | RTECS | UQ4900000 | | TSCA | Yes | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29331990 | | Toxicity | LD50 (24 hr) in rats, mice (mmol/kg): 19, 21 i.v.; 21, 22 orally (Magnussen) |
| | Pyrazole Usage And Synthesis |
| Chemical Properties | white to yellow crystals or crystalline powder | | Uses | Pyrazole is used in organic synthesis and asa chelating agent. | | Definition | ChEBI: 1H-pyrazole is the 1H-tautomer of pyrazole. It is a conjugate base of a pyrazolium. It is a conjugate acid of a pyrazol-1-ide. It is a tautomer of a 3H-pyrazole and a 4H-pyrazole. | | General Description | Pyrazine is a heterocyclic crystalline aromatic compound with a five-membered ring containing three carbon atoms and two nitrogen atoms. It is a symmetricdiazine. | | Hazard | Toxic by ingestion and inhalation, irritant
to skin and eyes.
| | Health Hazard | The acute toxic symptoms from oral administrationof pyrazole in experimental animalswere ataxia, muscle weakness, and respiratorydepression. It is less toxic than pyrroleand pyrrolidine. The oral LD50 value in miceis within the range 1450 mg/kg.
Pyrazole exhibited reproductive toxicityin rats and mice when administered by oralor intraperitoneal route. The effects includefetal death, developmental abnormalities pertainingto the urogenital system, and postimplantationmortality. | | Fire Hazard | Noncombustible solid. | | Safety Profile | Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx. | | Purification Methods | Crystallise pyrazole from pet ether, cyclohexane, or water. Its solubility in H2O at 9.6o is 2.7moles/L, and at 24.8o it is 19.4moles/L; in cyclohexane at 31.8o it is 0.577moles/L, and at 56.2o it is 5.86moles/L; and in benzene at 5.2o it is 0.31moles/L, and at 46.5o it is 16.8moles/1000mL. [Barszcz et al. J Chem Soc, Dalton Trans 2025 1986, Beilstein 23 H 39, 23 I 15, 23 II 33, 23 III/IV 550, 23/4 V 122.] |
| | Pyrazole Preparation Products And Raw materials |
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