N-Acetyl-L-tyrosine

N-Acetyl-L-tyrosine Basic information

Product Name:	N-Acetyl-L-tyrosine
Synonyms:	L-TYROSINE, N-ACETYL-;N-Acetyl-L-tryosine;ACETYLTYROSINE;ACETYL-L-TYROSINE;AC-TYR-OH;AC-TYROSINE;N-AC-L-TYR;N-ACETYL-L-TYROSINE
CAS:	537-55-3
MF:	C11H13NO4
MW:	223.23
EINECS:	208-671-3
Product Categories:	amino;Amino Acid;Tyrosine [Tyr, Y];Ac-Amino Acids;Amino Acids (N-Protected);Biochemistry;Amino Acid Derivatives;Amino Acids;Nutritional Supplements;Pharmaceutical Intermediates;N-Acetyl-Amino acid series;Amino acids;Biochemicals Found in Plants;Nutrition Research;Pharmacopoeial Amino AcidsPeptide Synthesis;Amino Acid Derivatives;Amino acidsPharmacopoeia (USP);Pharmacopoeia A-ZPharmacopoeia (USP);Tyrosine
Mol File:	537-55-3.mol

N-Acetyl-L-tyrosine Chemical Properties

Melting point	149-152 °C(lit.)
alpha	47.5 º (c=2, water)
Boiling point	364.51°C (rough estimate)
density	1.2446 (rough estimate)
refractive index	1.4960 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	H2O: soluble25mg/mL
pka	3.15±0.10(Predicted)
form	Crystalline
color	White to Off-White
Water Solubility	Soluble in water (25 mg/ml), and ethanol.
BRN	2697172
Stability:	Stable. Incompatible with strong oxidizing agents.
LogP	1.320
CAS DataBase Reference	537-55-3(CAS DataBase Reference)
NIST Chemistry Reference	N-acetyl-Tyr(537-55-3)
EPA Substance Registry System	N-Acetyl-L-tyrosine (537-55-3)

Safety Information

Hazard Codes	Xi
Risk Statements	41-36/37/38
Safety Statements	26-39-36
WGK Germany	3
F	10
TSCA	Yes
HS Code	29242995

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

N-Acetyl-L-tyrosine Usage And Synthesis

Chemical Properties	N-Acetyl-L-Tyrosine is a white crystalline powder that is an acetyl derivative of the amino acid, L-tyrosine. It is freely soluble in water compared to L-tyrosine and is commonly used as a parenteral nutrition supplement. N-Acetyl-L-tyrosine , a stable and more soluble form of tyrosine , has been incorporated in some currently available commercial parenteral amino acid formulations such as TrophAmine and Aminosyn-II.
Uses	N-Acetyl-L-tyrosine is involved in catecholamine production. It can be used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.
Definition	ChEBI: N-acetyl-L-tyrosine is an N-acetyltyrosine in which the chiral centre has L configuration. It has a role as an EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor, a biomarker and a human urinary metabolite. It is a N-acyl-L-tyrosine and a N-acetyltyrosine. It is a conjugate acid of a N-acetyl-L-tyrosinate.
Application	N-Acetyl-L-tyrosine is a tyrosine derivative with a chemical structure similar to that of an amino acid. It is used as a model system in biochemistry and molecular biology to study the transfer reactions of tyrosine, which are important for energy metabolism, protein synthesis, and metal chelation. N-acetyl-L-tyrosine may be used as an indicator to distinguish neurosyphilis patients from syphilis/non-neurosyphilis patients. N-acetyl-L-tyrosine is a precursor of the essential neurotransmitter dopamine.
benefits	N-Acetyl-L-Tyrosine (NALT) plays a necessary part in the synthesis of dopamine and other hormones in your body. It can boost levels of the neurotransmitters dopamine, norepinephrine and epinephrine. It helps to support higher levels of focus and cognitive function. It can increase working memory and feelings of well-being.
Side effects	L-tyrosine gets the generally regarded as safe (GRAS) stamp of approval from the FDA. Some side effects of N-Acetyl-L-tyrosine (NALT) include nausea, headache, fatigue, and heartburn. It can be safely taken for extended periods of time.

N-Acetyl-L-tyrosine Preparation Products And Raw materials

Raw materials

(Z)-2-acetamido-3-(4-hydroxyphenyl)acrylic acid-->2-ACETYL-3-(4-HYDROXYLPHENYL)-ACRYLICACID-->ethyl (2R)-2-acetamido-3-(4-hydroxyphenyl)propanoate-->N-ACETYL-D-TYROSINE ETHYL ESTER-->N-Acetyl-DL-Tyrosine Methyl Ester-->AC-D-TYR-OME-->Methyl L-tyrosinate-->N-Acetyl-DL-tyrosine-->AC-TYR-OME H2O-->AC-D-TYR-OH-->N-ACETYL-L-TYROSINE ETHYL ESTER-->L-Tyrosine

Acetyl-resveratrol N-ACETYL-L-TYROSINE ETHYL ESTER L-Tyrosine H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH TYROSINASE Acetylacetone Ethyl N-acetyl-L-tyrosinate hydrate CHLOROAC-TYR-OET Boc-D-Tyr-OH (H-CYS-TYR-OH)2 Acetyl chloride AC-3,5-DINITRO-TYR-OET Ethyl N-benzoyl-L-tyrosinate Acetyl coenzyme A sodium salt TYROSINASE FROM MUSHROOM BIOCHEMIKA, LYOPHILIZED, ≥2000 UNITS/MG N-Acetyl-L-tyrosine H-VAL-TYR-OH Ethyl 2-(acetylamino)-3-[3,5-diamino-4-(4-methoxyphenoxy)phenyl]propanoate

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