ISOFENPHOS

ISOFENPHOS Basic information
Product Name:ISOFENPHOS
Synonyms:OFTANOL;O-ETHYL O-2-ISOPROPOXYCARBONYLPHENYL ISOPROPYL PHOSPHORAMIDO THIOATE;2-((ethoxy((1-methylethyl)amino)phosphinothioyl)oxy)-benzoicaci1-methyl;2-((ethoxy((1-methylethyl)amino)phosphinothioyl)oxy)benzoicacid1-methylethy;2-(o-aethyl-n-isopropylamidothiophosphoryloxy)-benzosaeure-isopropylester;pyrfon;salicylicacid,isopropylester,o-esterwitho-ethylisopropylphosphoramidothi;AMAZE(R)
CAS:25311-71-1
MF:C15H24NO4PS
MW:345.39
EINECS:246-814-1
Product Categories:Alpha sort;H-MAnalytical Standards;Pesticides&Metabolites;Alphabetic;Analytical Standards;Insecticides;IPesticides;Organophorous
Mol File:25311-71-1.mol
ISOFENPHOS Structure
ISOFENPHOS Chemical Properties
Melting point -12℃
Boiling point bp0.01 120°
density 1.131 g/cm3 (20 ºC)
vapor pressure 2.2 x 10-4 Pa (20 °C)
storage temp. 0-6°C
solubility Chloroform (Slightly), DMSO (Slightly)
Water Solubility 18 mg l-1 (20 °C)
pka-0.30±0.70(Predicted)
form Oil
color Colourless
CAS DataBase Reference25311-71-1(CAS DataBase Reference)
EPA Substance Registry SystemIsofenphos (25311-71-1)
Safety Information
Hazard Codes T,N,Xn,F
Risk Statements 24/25-50/53-52/53-36-20/21/22-11
Safety Statements 36/37-45-60-61-26-16
RIDADR 3018
WGK Germany 2
RTECS VO4395500
HazardClass 6.1(a)
PackingGroup I
HS Code 29299090
Hazardous Substances Data25311-71-1(Hazardous Substances Data)
ToxicityLD50 orally in rats, mice (mg/kg): 30-40, 90-130 (Homeyer)
MSDS Information
ISOFENPHOS Usage And Synthesis
Chemical PropertiesIsofenphos is a colorless oil at room temperature. It is sparingly soluble in water, but soluble in cyclohexone, toluene, acetone, and diethyl ether. The US EPA has grouped isofenphos under RUP, which indicates that qualifi ed, certifi ed, and trained workers are required in the safety management of isofenphos. It is used on turf and ornamental trees and shrubs to control white grubs, mole crickets, and other insects, such as soil-dwelling insects, cabbage root fl ies, corn roundworms, and wire worms.
UsesInsecticide.
UsesIsofenphos is used as a systemic insecticide to control cabbage root flies, carrot flies, onion flies and other soil insects in vegetables, rape, maize, bananas, sugar cane and other crops.
UsesIsofenphos is an organophosphorus insecticide used in soil to control leaf-eating and soil-dwelling pests in vegetables, fruits, turf and field crops.
DefinitionChEBI: Isofenphos is an organothiophosphate insecticide, an organic phosphonate, a phosphonic ester, a member of salicylates and an isopropyl ester. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical. It is functionally related to an isopropyl salicylate.
General DescriptionColorless oil. Non corrosive. Used as an insecticide.
Air & Water ReactionsHydrolyzed by alkali solution.
Reactivity ProfileOrganothiophosphates, such as ISOFENPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health HazardExposures to isofenphos are highly toxic to animals and humans. Acute and prolonged exposures to high concentrations of isofenphos has caused poisoning with symptoms such as increased secretions, diffi culty in breathing, diarrhea, urination, pupil contraction, slowness of the heart, convulsions, and coma. Isofenphos in combination with malathion cause severe poisoning in humans.
Environmental FateSoil. Rapidly degraded by microbes via oxidative desulfuration in soils forming isofenphos oxon (Abou-Assaf et al., 1986; Abou-Assaf and Coats, 1987; Somasundarum et al., 1989), isopropyl salicylate and carbon dioxide (Somasundaram et al., 1989). The formation of isofenphos oxon is largely dependent upon the pH, moisture and temperature of the soil. The degradation rate of isofenphos decreased with a decrease in temperature (35°C >25°C >15°C), moisture content (22.5% >30% >15%) and in acidic and alkaline soils (pH 6 and 8 >pH 7). After isofenphos was applied to soil at a rate of 1,12 kg/ai/ha, concentrations of 8.3, 7.2, 5.1 and 1.0 ppm were found after 5, 21, 43 and 69 days, respectively. Following a second application, 4.9, 1.55, 0.25 and 0.10 ppm of isofenphos were found after 5, 21, 43 and 69 days, respectively (Abou-Assaf and Coats, 1987).
A pure culture of Arthrobacter sp. was capable of degrading isofenphos at different soil concentrations (10, 50 and 100 ppm) in less than 6 hours. In previously treated soils,isofenphos could be mineralized to carbon dioxide by indigenous microorganisms (
Plant. Two weeks following application to thatch, 65% of the applied amount was present (Sears et al., 1987).
Surface Water. In estuarine water, the half-life of isofenphos ranged from 9.8 to 11.9 days (Lacorte et al., 1995).
Photolytic. Irradiation of an isofenphos (500 mg) in hexane and methanol (100 mL) using a high pressure mercury lamp (l = 254–360 nm) for 24 hours yielded the following products: isofenphos oxon and O-ethyl hydrogen-N-isopropylphosphoroamidothioa
Metabolic pathway14C-Isofenphos is bioactivated by mixed-function oxidases that ultimately give N-desisopropylisofenphos oxon, a product with 2300-fold greater inhibitory potency than isofenphos oxon towards housefly head acetylcholinesterase.271 By housefly and the cuperous chafer, isofenphos is metabolized to give detoxified metabolites without the bioactivated N- desisopropylisofenphos oxon. No difference in kinds of metabolite is found between the two insects. When rats are administered 14C-isofenphos, most of the radioactivity is recovered from the water fraction of the urine and feces. Aminoisofenphos and isofenphos oxon are detected in the benzene fraction, and the other six metabolites are identified as water-soluble metabolites which include O-ethylhydrogen phosphoramidate and O-ethylhydrogen isopropylphosphoramidothioate. Water-soluble metabolites are predominantly formed through cleavage of the P-O-aryl linkage.
MetabolismMain degradation route is cleavage of the P?O-aryl ester linkage through oxidative desulfuration to isofenphos oxon followed by hydrolysis and oxidative dearylation from isofenphos. In plant, the major metabolites are salicylic acid and dihydroxybenzoic acid.
Toxicity evaluationThe acute oral LD50 for rats is about 20 mg/kg. Inhalation LC50 (4 h) for rats is 0.3–0.5 mg/L air. NOEL (2 yr) for rats 1 mg/kg diet (0.05 mg/kg/d). ADI is 1 μg/kg. In mammals, administered isofenphos is rapidly metabolized and eliminated; almost 95% is excreted within 24 h in the urine and feces. The active metabolite is des-N-isopropylisofenphos oxon.
DegradationIsofenphos is stable to hydrolysis with a DT50 of >1 year at pH values from 4 to 9. Photodegradation on soil surfaces in the laboratory was extremely rapid but under natural light conditions photolysis was slower (PM).
Ethyl 2-hydroxybenzoate Isocarbophos Isofenphos methyl granule ISOFENPHOS-DES-N-ISOPROPYL 100UG/ML IN HEXANE 1ML [R] ISOFENPHOS SOLUTION 100UG/ML IN ACETONITRILE 1ML Isofenphos-methyl PESTANAL,ISOFENPHOS-METHYL ISOFENPHOS OXON STANDARD,ISOFENPHOS-OXON,ISOFENPHOS-O-ANALOGUE methyl isofenphos Isofenphos methyl E.C.,synergistic ISOFENPHOS-DES-N-ISOPROPYL-O-ANALOGUE 10NG/UL IN CYCLOHEXANE 5ML [R] ISOFENPHOS SOLUTION 100UG/ML IN TOLUENE 1ML ISOFENPHOS Isopropyl salicylate ISOFENPHOS-DES-N-ISOPROPYL ISOFENPHOS-DES-N-ISOPROPYL-OXON,ISOFENPHOS-DES-N-ISOPROPYL-O-ANALOGUE O,O-Dimethyl phosphoramidothioate Isofenphos methyl E.C. ISOFENPHOS-DES-N-ISOPROPYL 100MG [R]

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