(R)-(-)-2-(2,5-Dihydrophenyl)glycine

(R)-(-)-2-(2,5-Dihydrophenyl)glycine Basic information
Product Name:(R)-(-)-2-(2,5-Dihydrophenyl)glycine
Synonyms:Cefradine Impurity B(EP);(R)-alpha-aminocyclohexa-1,4-diene-1-acetic acid;D-(-)-alpha-2,5-Dihydrophenylglycine;(R)-(-)-2-(2,5-DIHYDROPHENYL)GLYCINE, 98;D-(-)-Dihydro-alpha-phenylglycine;(r)-à-amino-1-(1,4-cyclohexadienyl)acetic acid;(r)-α-amino-1,4-cyclohexadiene-1-acetic acid;L--Dihydrophenylglycine
CAS:26774-88-9
MF:C8H11NO2
MW:153.18
EINECS:247-999-1
Product Categories:Pharmaceutical Intermediates
Mol File:26774-88-9.mol
(R)-(-)-2-(2,5-Dihydrophenyl)glycine Structure
(R)-(-)-2-(2,5-Dihydrophenyl)glycine Chemical Properties
Melting point 280 °C (dec.) (lit.)
alpha -154 º (c=1 in H2O)
Boiling point 276.1°C (rough estimate)
density 1.1577 (rough estimate)
refractive index -155 ° (C=1, 1mol/L HCl)
storage temp. -20°C
solubility Aqueous Acid (Slightly)
pka2.17±0.10(Predicted)
form neat
color White
optical activity[α]20/D 154°, c = 1 in H2O
BRN 2091420
CAS DataBase Reference26774-88-9(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 2922.49.8000
MSDS Information
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(R)-(-)-2-(2,5-Dihydrophenyl)glycine Usage And Synthesis
Chemical Propertieswhite powder
Uses(R)-(-)-2-(2,5-Dihydrophenyl)glycine is a cycohexadiene based amino acid used in the preparation of cephalosporin-type antibiotics such as Cephradine (C261800).
(R)-(-)-2-(2,5-Dihydrophenyl)glycine Preparation Products And Raw materials
Preparation ProductsD-dihydrophenylglycine methyl ester-->2-amino-2-(cyclohexadien-1,4-yl)acetic acid
(2R)-2-AMINO-2-(2,3,4,6-TETRAMETHOXYPHENYL)PROPANOIC ACID Ethyl 2-(Chlorosulfonyl)acetate Acetic anhydride Chloroacetic acid 2-Aminocyclohexanol GlycineMax Cyclohexa-1,4-diene α-Lipoic Acid Glycine o-Aminophenylacetic acid 4-Aminophenylacetic acid (R)-(-)-2-(2,5-Dihydrophenyl)glycine 4-tert-Butylcyclohexyl acetate Anilinoacetic acid Iminodiacetic acid 4-Hydroxy-D-(-)-2-phenylglycine Molasses Nitrilotriacetic acid

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