4,7-Dichloroquinoline

4,7-Dichloroquinoline Basic information

Product Name:	4,7-Dichloroquinoline
Synonyms:	4,7-DICHLOROQUINOLINE;TL 1473;tl1473;4,7-Dichloroquinoline,97%;4,7-DICHLOLROQUINOLINE;4,7-DICHLOROQUINOLINE CHLOROQUINE PHOSPHATE;7-Dichloroquinoline;Chloroquine Related Compound A (25 mg) (4,7-dichloroquinoline)
CAS:	86-98-6
MF:	C9H5Cl2N
MW:	198.05
EINECS:	201-714-7
Product Categories:	Building Blocks;C8 to C10;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Haloquinolines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;QuinolinesHeterocyclic Building Blocks;Quinolines, Quinazolines and derivatives;Quinoline&Isoquinoline;Quinolines
Mol File:	86-98-6.mol

4,7-Dichloroquinoline Chemical Properties

Melting point	81-83 °C (lit.)
Boiling point	298.4 °F (148°C)
density	1.4178 (rough estimate)
vapor pressure	0.103Pa at 25℃
refractive index	1.6300 (estimate)
Fp	164 °C
storage temp.	2-30°C
solubility	chloroform: soluble50mg/mL, clear, colorless to greenish-yellow
form	Powder
pka	1.99±0.27(Predicted)
color	White to pale brown
Water Solubility	insoluble
BRN	125359
InChIKey	HXEWMTXDBOQQKO-UHFFFAOYSA-N
LogP	3.193 at 25℃
CAS DataBase Reference	86-98-6(CAS DataBase Reference)
NIST Chemistry Reference	Quinoline, 4,7-dichloro-(86-98-6)
EPA Substance Registry System	4,7-Dichloroquinoline (86-98-6)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-22
WGK Germany	3
RTECS	VB4200000
Hazard Note	Irritant
TSCA	Yes
HS Code	29334910

MSDS Information

Provider	Language
4,7-Dichloroquinoline	English
SigmaAldrich	English
ACROS	English
ALFA	English

4,7-Dichloroquinoline Usage And Synthesis

Chemical Properties	white to light yellow crystal powder
Uses	4,7-Dichloroquinoline is used as a drug chloroquine phosphate intermediate. It was used in the synthesis of piperaquine. and as starting reagent in the synthesis of {3-amino-5-[(7-chloro-4-quinolyl)amino]phenyl}methanol.
Uses	4,7-Dichloroquinoline is used in the synthesis of hybrid aminoquinoline-triazine derivatives that show anti-microbial activity. In addition, it is used in the synthesis of novel oxazolidinones as anti -microbial agents showing efficacy against common bacterial strains. Chloroquinoline impurity.
General Description	Chloroquine Related Compound A is an impurity of chloroquine, which is a 9-aminoquinoline drug that effectively inhibits viral infections in humans.
Flammability and Explosibility	Notclassified
Synthesis	4,7-Dichloroquinoline is obtained by chlorination of 7-chloro-4-hydroxyquinoline.
Purification Methods	Crystallise the dichloroquinoline from MeOH or 95% EtOH. [Beilstein 20/7 V 316.]

4,7-Dichloroquinoline Preparation Products And Raw materials

Raw materials	7-Chloroquinolin-4-ol
Preparation Products	4-BROMO-7-CHLOROQUINOLINE-->7-Chloro-4-piperazinoquinoline-->Hydroxychloroquine-->CHLOROQUINE-->7-chloroquinoline-4-carboxylic acid-->4-Methoxyquinoline-->DESETHYL HYDROXY CHLOROQUINE-->N-(7-Chloro-4-quinolinyl)-N'-[2-[(7-chloro-4-quinolinyl)aMino]ethyl]-1,2-ethanediaMine-->Quinoline, 3,4,7-trichloro--->4-Chloro-5,6,7,8-tetrahydroquinoline-->4,7,8-TRICHLOROQUINOLINE-->Amodiaquine

4,7-DICHLOROQUINOLINE-15N ETHYL 4,5,7-TRICHLORO-3-QUINOLINECARBOXYLATE 2-METHYL-4,7,8-TRICHLOROQUINOLINE 4,7-DICHLORO-2,8-DIMETHYLQUINOLINE ETHYL 4,7,8-TRICHLORO-3-QUINOLINECARBOXYLATE 3，7-Dichloroquinoline acid-8,3,7-DICHLOROQUINOLINE-8-CARBOXYLIC ACID 4,7-DICHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ETHYL ESTER 2,4,7-TRICHLORO-8-METHYL-3-PHENYLQUINOLINE 4,7-DICHLORO-2-METHYLQUINOLINE 7,10-dichloro-2-methoxybenzo[b]-1,5-naphthyridine 4,7-DICHLORO-8-METHYLQUINOLINE 4,5,7-TRICHLORO-2-(TRIFLUOROMETHYL)QUINOLINE chloroquinoline 1,2-Dichloro-4-(chloromethyl)benzene 2,4,7,8-TETRACHLORO-3-PHENYLQUINOLINE 1-AZA-2-N-BUTOXY-6,9-DICHLORO-ACRIDINE 4,7-DICHLOROQUINOLINE, [3H]- ETHYL 4,7-DICHLORO-6-FLUOROQUINOLINE-3-CARBOXYLATE

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