o-Cresolphthalein

o-Cresolphthalein Basic information
Product Name:o-Cresolphthalein
Synonyms:3’,3’’-dimethyl-phenolphthalei;cresolphthalein;Di-o-Cresolphthalide;o-Cresolphalein;o-cresolphtaleine;3,3-bis(4-hydroxy-3-methylphenyl)-(3H)-Isobenzofuranone;3,3-bis(4-hydroxy-3-methylphenyl)-1(3h)-isobenzofuranon;3,3-Bis(4-hydroxy-3-methylphenyl)-1-(3H)-iso-benzofuranone
CAS:596-27-0
MF:C22H18O4
MW:346.38
EINECS:209-881-8
Product Categories:Phthalein;Analytical Chemistry;Indicator (pH);pH Indicators;CTitration;Indicators;pH Indicators - Solids;Stains and Dyes;Stains&Dyes, A to
Mol File:596-27-0.mol
o-Cresolphthalein Structure
o-Cresolphthalein Chemical Properties
Melting point 223-225 °C
Boiling point 401.12°C (rough estimate)
density 1.1425 (rough estimate)
refractive index 1.4400 (estimate)
solubility Solubility Slightly soluble in water; soluble in ethanol
pka9.40(at 25℃)
form powder
color Clear colorless
PH Range8.2 (colorless) - 9.8 (violet/red)
Water Solubility slightly soluble
λmax566nm, 381nm
Merck 14,2576
BRN 310554
Major ApplicationSensors, display device, photoresists, recording materials, imaging materials, authentication system for secure documents, decoder system, lithium cells, electroplating process, inks, markers, toners, correction fluid, paints, adhesives, floor coatings, gas leaking detector for safety in industries, toys, food storage, diapers, determination of calcium, lotions, urine analysis test strips, drugs, blood analysis
InChIKeyCPBJMKMKNCRKQB-UHFFFAOYSA-N
CAS DataBase Reference596-27-0(CAS DataBase Reference)
EPA Substance Registry System1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxy-3-methylphenyl)- (596-27-0)
Safety Information
Hazard Codes Xn
Risk Statements 40-36/37/38-20/21/22
Safety Statements 36/37-36-26
RIDADR 1170
WGK Germany 3
RTECS SM8390000
TSCA Yes
HS Code 3822.19.0080
MSDS Information
ProviderLanguage
3,3-Bis(4-hydroxy-3-methylphenyl)-1(3H)-isobenzofuranone English
ACROS English
ALFA English
o-Cresolphthalein Usage And Synthesis
Chemical Propertieswhite to pink or beige to tan powder. soluble in ethanol, ether, glacial acetic acid, soluble in dilute alkali and turns purple, slightly soluble in water, hardly soluble in benzene.
UsesO-Cresolphthalein has been used as a component in calcifying media for calcification assay. It is also used as an indicator (pH range, 8.2 colorless, 9.8 red) and analytical reagent.
ApplicationO-Cresolphthalein is a gadolinium chelate that is used as a contrast agent for magnetic resonance imaging (MRI) of the brain, spine, and joints. The gadolinium ion is bound to the cresol molecule, which has an attached hydroxyl group. This complex attaches to the phosphorous pentoxide and creates a precipitate of metal hydroxides in the presence of water and sodium carbonate. O-Cresolphthalein is also used in clinical pathology to measure glomerular filtration rate (GFR), which is important for diagnosing renal disease. MRI scans are used to diagnose osteogenic genes that are associated with bone diseases such as osteoporosis.
Biochem/physiol Actionso-Cresolphthalein is a reversible pH indicator. The kinetics of the reverse pathway (red-purple to colorless) is slow, thereby making it an appropriate molecule to check flow patterns in ducts with corrugated walls. It is also used for the colorimetric determination of calcium content via the o-cresolphthalein complexone method. Binding of calcium to o-cresolphthalein, in the presence of alkaline conditions (pH 10-12), results in the formation of a red complex with an absorbance at 570-575nm.
o-Cresolphthalein Preparation Products And Raw materials
Raw materialsZinc chloride-->o-Cresol-->ORTHO TOLUENE
Chlorodimethylphenylsilane Thymolphthalein monophosphate 2-amino-2-methyl-1,3-propanediol salt FURFURYL ALCOHOL RESIN Phenylacetone O-Methyl phenolic epoxy resin Phenolphthalein PHENOLPHTHALEIN COMPLEXONE Carbofuran o-Cresol BCECF-AM THYMOLPHTHALEIN MONOPHOSPHATE DISODIUM SALT o-Cresolphthalein Tetrahydrofuran O-CRESOLPHTHALEIN COMPLEXONE TETRASODIUM SALT Thymolphthalein Complexone THYMOLPHTHALEIN MONOPHOSPHATE MAGNESIUM SALT Furazolidone CHLOROPHOSPHONAZO III

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