2-Bromo-5-nitropyridine

2-Bromo-5-nitropyridine Basic information

Product Name:	2-Bromo-5-nitropyridine
Synonyms:	TIMTEC-BB SBB003519;2-BROMO-5-NITROPYRIDINE;2-BROMO-5-NITROPYRIDINE 97%;2-BROMO-5-NITROPYRIDINE 2-BROMO-5-NITROPYRIDINE;2-BORMO-5-NITROPYRIDINE;2-BroMo-5-nitropyridine, 98% 1GR;5-Nitro-2-broMopyridine;NSC 73702
CAS:	4487-59-6
MF:	C5H3BrN2O2
MW:	202.99
EINECS:	224-777-2
Product Categories:	Brominated heterocyclic series;Boronic Acid;Pyridines derivates;C5Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyridine series;Halides;Pyridine;Nucleotides and Nucleosides;Bromopyridines;Halopyridines;Bases & Related Reagents;Nucleotides;compounds of pyridine;pyridines;blocks;Bromides;NitroCompounds;pyridine derivative;Pyridines, Pyrimidines, Purines and Pteredines;Building Blocks/Intermediates
Mol File:	4487-59-6.mol

2-Bromo-5-nitropyridine Chemical Properties

Melting point	139-141 °C (lit.)
Boiling point	145-147 °C/10 mmHg (lit.)
density	1.8727 (rough estimate)
refractive index	1.6200 (estimate)
Fp	145-147°C/10mm
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform, Hot Methanol
form	Crystalline Powder
pka	-3.24±0.10(Predicted)
color	Light yellow to light brown
Water Solubility	Insoluble in water.
BRN	120901
InChIKey	HUUFTVUBFFESEN-UHFFFAOYSA-N
CAS DataBase Reference	4487-59-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38-20/21/22
Safety Statements	26-37/39-22-36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
Hazard Note	Irritant/Keep Cold
HazardClass	IRRITANT, IRRITANT-HARMFUL
PackingGroup	III
HS Code	29333990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

2-Bromo-5-nitropyridine Usage And Synthesis

Chemical Properties

Off-white to light yellow crystal.

Uses

2-Bromo-5-nitropyridine was used in preparation of boc-protected (piperazin-1-ylmethyl)biaryls via microwave-mediated Suzuki-Miyaura coupling with (boc-piperazin-1-ylmethyl)phenylboronic acid pinacol esters. It was also used in the synthesis of 2-pyridyl analogs. Substituted 5-nitro-2-ethynylpyridines were synthesized by the Sonogashira reaction of 2-bromo-5-5-nitropyridine with terminal acetylenes.

2-Bromo-5-nitropyridine Preparation Products And Raw materials

Raw materials

Ethanol-->Phosphorus tribromide-->Phosphorus oxybromide-->2-Hydroxy-5-nitropyridine

Preparation Products

2-Bromo-5-hydroxypyridine radical ion(1+)-->5-AMINOPYRIDINE-2-SULFONIC ACID-->6-(AMINOMETHYL)-3-AMINOPYRIDINE-->5-Amino-2-bromopyridine-->5-ACETAMIDO-2-BROMOPYRIDINE-->3-Aminopyridine-->2-Methyl-5-nitropyridine-->ethyl 4,6-dichloro-1,5-naphthyridine-3-carboxylate-->6-Iodo-3-nitropyridine-->4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER-->5-Nitropyridine-2-carboxylic acid-->5-HYDROXYPYRIDINE-2-CARBOXYLIC ACID-->3-Amino-6-morpholinopyridine-->5-Bromopicolinic acid-->N,N-diMethyl-6-nitropyridin-3-aMine-->5-Nitro-2-(4-vinylphenyl)pyridine

2,3,6-TRIBROMO-4-METHOXY-5-NITROPYRIDINE 1-Hexadecylpyridinium bromide 2,4-DIBROMO-5-NITROPYRIDINE 2-BROMO-3,5-DINITROPYRIDINE 2,6-Dibromo-3-nitropyridine 2-Amino-6-bromo-3-nitropyridine 4-Amino-2,6-dibromo-3-nitropyridine N1-(1-BROMO-4-NITRO-3-ISOQUINOLYL)BENZAMIDE 2-BROMO-5-NITROPYRIDIN-4-AMINE 2-Bromo-3-methyl-5-nitropyridine 2-BROMO-3-CHLORO-5-NITROPYRIDINE 3-Bromonitrobenzene Nitrobenzene 2-Bromo-5-nitro-4-picoline 6-BROMO-2-METHOXY-3-NITRO-PYRIDINE 2-Bromo-5-nitropyridine-1-oxide 2,3-DIBROMO-5-NITRO PYRIDINE 2-BROMO-3-IODO-5-NITROPYRIDINE

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2-Bromo-5-nitropyridine

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