2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Basic information
Reaction
Product Name:2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl
Synonyms:2-DICYCLOHEXYLPHOSPHINO-2'-(N,N-DIMETHY&;2-(DICYCLOHEXYLPHOSPHINO)-2'-(DIMETHYLAMINO)BIPHENYL;2-DICYCLOHEXYLPHOSPHINO-2'-(N,N-DIMETHYLAMINO)BIPHENYL;2-Dicyclohexylphosphino-2'-(N,;2-(Dicyclohexylphosphino)-2'-(N,N-dimethylamino)biphenyl,98%DavePhos;2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)-;[1,1''-BIPHENYL]-2-AMINE, 2''-(DICYCLOHEXYLPHOSPHINO)-N,N-DIMETHYL-;2-Dicgclohexylphosphino-2’-(N,N-dimethylamino)biphenyl
CAS:213697-53-1
MF:C26H36NP
MW:393.54
EINECS:606-749-5
Product Categories:Buchwald Ligands&Precatalysts;Achiral Phosphine;Aryl Phosphine;Buchwald Ligands Series;Phosphines;Biphenyl & Diphenyl ether;Phosphine Ligands;Synthetic Organic Chemistry
Mol File:213697-53-1.mol
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Structure
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Chemical Properties
Melting point 121-124 °C(lit.)
Boiling point 539.6±43.0 °C(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka5.04±0.18(Predicted)
form crystal
color white
Water Solubility Insoluble
Sensitive Air Sensitive
InChIKeyZEMZPXWZVTUONV-UHFFFAOYSA-N
CAS DataBase Reference213697-53-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 26-36/37/39
WGK Germany 3
TSCA No
HazardClass AIR SENSITIVE
HS Code 29310099
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Usage And Synthesis
Reaction
  1. Ligand used in the Pd-catalyzed Suzuki coupling and animation of unactivated aryl chlorides. The reactions generally occur at room temperature and give high yields of product.
  2. Ligand used in Pd-catalyzed C-N bond formation. A general synthesis of N6-aryl-2'deoxyadenosine analogues.
  3. Ligand used in Pd-catalyzed N-arylation of indoles.
  4. Ligand used in Pd-catalyzed synthesis of aryl-tert-butyl ethers.
  5. Effective ligand in the Pd-catalyzed arylation of ester enolates.
  6. Ligand employed in arylation of ketone enolates using ortho-halo nitrobenezenes.
  7. Ligand employed in the amination of aryl nonaflates using Pd catalysts.
  8. Ligand used for cascade alkenyl amination/Heck reaction for the synthesis of indoles.
  9. Ligand used in Pd-catalyzed Kumada-Corriu cross coupling at low temperatures.
  10. Ligand used in Rh-catalyzed intramolecular hydroamination of unactivated terminal and internal alkenes with primary and secondary amines.
  11. Ligand used in Au-catalyzed cycloisomerization of allenes.
Reactions of 213697-53-1_1
Reactions of 213697-53-1_2
Description2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. It binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains.
Chemical Propertieswhite to light yellow crystals or
Uses2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl can act as ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chlorides.
UsesEffective ligand in the Pd-catalyzed arylation of ester enolates
Usessuzuki reaction
Application2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylacts as a growth regulator by binding to Toll-like receptor 4 (TLR4), which is important in cytokine signaling. It also inhibits allyl carbonate production and cross coupling reactions between aryl chlorides and nitrogen atoms or amines. It has an inhibitory effect on depression, but this effect is not related to its inhibitory effect on bromodomains.
2-(Dicyclohexylphosphino)biphenyl 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 2-(Dicyclohexylphosphino)-2'-methylbiphenyl CYCLOHEXYLPHOSPHINE DIBUTYLPHENYLPHOSPHINE DI-N-PENTYLPHENYLPHOSPHINE Biphenyl DICYCLOHEXYLPHOSPHINE m-xylenediamine 3-Dimethylaminopropylamine Dicyclohexylphenylphosphine Dimethylamine hydrochloride 1,3-Bis(aminomethyl)benzene 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Minocycline N,N-Dimethylbenzylamine Dimethylamine

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.