| | 1-Bromopentane Basic information |
| | 1-Bromopentane Chemical Properties |
| Melting point | −95 °C(lit.) | | Boiling point | 130 °C(lit.) | | density | 1.218 g/mL at 25 °C(lit.) | | vapor density | >1 (vs air) | | refractive index | n20/D 1.444(lit.) | | Fp | 88 °F | | storage temp. | Flammables area | | solubility | H2O: insoluble | | form | Liquid | | color | Clear colorless to light yellow | | Water Solubility | practically insoluble | | Merck | 14,602 | | BRN | 1730981 | | Stability: | Stable. Flammable. Incompatible with strong oxidizing agents, strong bases. | | InChIKey | YZWKKMVJZFACSU-UHFFFAOYSA-N | | CAS DataBase Reference | 110-53-2(CAS DataBase Reference) | | NIST Chemistry Reference | Pentane, 1-bromo-(110-53-2) | | EPA Substance Registry System | Pentane, 1-bromo- (110-53-2) |
| Hazard Codes | Xi,F,N,Xn | | Risk Statements | 10-36/37/38-51/53-22 | | Safety Statements | 26-36-61-37/39-29-16 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 2 | | RTECS | RZ9770000 | | Hazard Note | Irritant/Flammable | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29033036 | | Toxicity | LD50 ipr-mus: 1250 mg/kg GTPZAB 20(12),52,76 |
| | 1-Bromopentane Usage And Synthesis |
| Chemical Properties | liquid | | Uses | 1-Bromopentane is a chemical reagent used in a multitude of organic syntheses. It is used iron-catalyzed alkylations of aromatic Grignard reagents via cross coupling. It is used in the synthesis of α,
γ-diketo acids as reversible inhibitors of Hepatitis C virus NS5b RNA polymerase. | | Uses | 1-Bromopentane is used in a multitude of organic synthesis. It is used in iron-catalyzed alkylations of aromatic Grignard reagents via cross coupling. | | Synthesis Reference(s) | Journal of the American Chemical Society, 86, p. 5037, 1964 DOI: 10.1021/ja01076a084 | | General Description | 1-Bromopentane undergoes phase transfer catalysed alkylation reaction with 2′-hydroxy acetophenone using tetrabutyl ammonium bromide as catalyst. | | Safety Profile | Moderately toxic byintraperitoneal route. Slightly toxic by inhalation. Whenheated to decomposition it emits toxic vapors of Br-. | | Purification Methods | Wash the bromide with conc H2SO4, then water, 10% Na2CO3 solution, again with water, dry with CaCl2 or K2CO3, and fractionally distil it just before use. [Beilstein 1 IV 312.] |
| | 1-Bromopentane Preparation Products And Raw materials |
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