Methacetin

Methacetin Basic information

Product Name:	Methacetin
Synonyms:	p-Acetanasidine~N-(Methoxyphenyl)acetamide;p-Acetanasidine;p-Acetoanisidide;4'-Methoxyacetanilide, 99+%;n-(methoxyphenyl)acetamide;p-acetaniside;acetaniside;p-acetylanisidine
CAS:	51-66-1
MF:	C9H11NO2
MW:	165.19
EINECS:	200-114-2
Product Categories:	Intermediates of Dyes and Pigments;Anilines, Amides & Amines;Anisoles, Alkyloxy Compounds & Phenylacetates;Aromatics;Diagnostic
Mol File:	51-66-1.mol

Methacetin Chemical Properties

Melting point	128-130 °C(lit.)
Boiling point	293.03°C (rough estimate)
density	1.1603 (rough estimate)
refractive index	1.5839 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	14.53±0.70(Predicted)
form	Crystalline
color	White
Water Solubility	0.42 g/100 mL (20 ºC)
Merck	14,51
BRN	387887
Stability:	Hygroscopic
CAS DataBase Reference	51-66-1(CAS DataBase Reference)
NIST Chemistry Reference	N-(4-Methoxyphenyl)acetic acid amide(51-66-1)
EPA Substance Registry System	Acetamide, N-(4-methoxyphenyl)- (51-66-1)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/38
Safety Statements	36-37/39-26
WGK Germany	1
RTECS	AE8290000
TSCA	Yes
HS Code	29242990
Toxicity	LD50 orl-mus: 1190 mg/kg TXAPA9 19,20,71

MSDS Information

Provider	Language
N-(4-Methoxyphenyl)acetamide	English
ACROS	English
SigmaAldrich	English
ALFA	English

Methacetin Usage And Synthesis

Chemical Properties	LIGHT BEIGE CRYSTALLINE POWDER
Uses	Methacetin is evaluated in a breath test to predict early liver disfunction due to valproic acid and other cause. Methacetin breath test (MBT) is a rapid, non-invasive assessment of liver function in acute severe liver disease and a potential key tool in future dignosis.
Definition	ChEBI: Methacetin is a member of the class of acetamides that is paracetamol in which the hydrogen of phenolic hydroxy group has been replaced by a methyl group. It is a member of acetamides and an aromatic ether. It is functionally related to a p-anisidine and a paracetamol.
Synthesis Reference(s)	Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061 The Journal of Organic Chemistry, 42, p. 3755, 1977 Organic Syntheses, Coll. Vol. 3, p. 661, 1955
Safety Profile	Moderately toxic by ingestion andother unspecified routes. When heated to decomposition itemits toxic fumes of NOx.

Methacetin Preparation Products And Raw materials

Raw materials	Acetic acid-->p-Anisidine
Preparation Products	Disperse Blue 79-->Azoic Diazo Component 1-->4-METHOXY-2-NITROACETANILIDE-->N-(4-METHOXY-3-NITROPHENYL)ACETAMIDE-->4-Bromo-3-nitroanisole-->3,4-Dimethoxyphenol-->2,6-DICHLORO-1,4-BENZOQUINONE-->TRIPHENYLFLUOROSILANE-->2,5-DIBROMOANISOLE-->Acetaminophen-->Diazo Fast Bordeaux GP

3'-Amino-4'-methoxyacetanilide N-(4-METHOXYPHENYL)MALEAMIC ACID 3-HYDROXY-P-BUTYROPHENETIDINE 10,11-Dimethoxystrychnine 2-cyano-N-(2,4-dimethoxyphenyl)acetamide 4'-Methoxyacetoacetanilide 3-Hydroxy-4'-methoxy-2-naphthanilide 4-CHLORO-N-(4-ETHOXYPHENYL)BENZAMIDE N-(4-ETHOXYPHENYL)MALEAMIC ACID 2-Chloro-p-acetophenetidide Phenacetin Methacetin Lactyl Phenetidine N-(2-Hydroxynaphthoyl)-2,4-dimethoxy-5-chloroanilide BRUCINE SULFATE N-(4-ETHOXY-PHENYL)-SUCCINAMIC ACID 2-CHLORO-N-(4-METHOXY-PHENYL)-ACETAMIDE 2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER

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