Trimebutine

Trimebutine Basic information
Product Name:Trimebutine
Synonyms:3,4,5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL;3,4,5-TRIMETHOXYBENZOIC ACID 2-[DIMETHYLAMINO]-2-PHENYLBUTYL ESTER;TRIMEBUTIN;TRIMEBUTINE;trimebutine free base;Trimebutine hydrochloride;TRIMEBUTINE3.4.5-TRIMETHOXYBENZOATE,-2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL;TrimebutineMeleate34140-59-5/Base
CAS:39133-31-8
MF:C22H29NO5
MW:387.47
EINECS:254-309-2
Product Categories:API;ACTIVE PHARMACEUTICAL INGREDIENTS
Mol File:39133-31-8.mol
Trimebutine Structure
Trimebutine Chemical Properties
Melting point 78-80°C
Boiling point 513.42°C (rough estimate)
density 1.1998 (rough estimate)
refractive index 1.5614 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
form neat
pka7.29±0.50(Predicted)
color White to Off-White
Water Solubility 10g/L
Merck 14,9699
CAS DataBase Reference39133-31-8(CAS DataBase Reference)
Safety Information
WGK Germany 3
HS Code 2922.19.0900
MSDS Information
Trimebutine Usage And Synthesis
UsesTrimebutine is an opioid receptor agonist and an antispasmodic agent (1,2). It is used to treat acute and chronic abdominal pain.
UsesTrimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain.
DefinitionChEBI: 3,4,5-trimethoxybenzoic acid [2-(dimethylamino)-2-phenylbutyl] ester is a trihydroxybenzoic acid.
Trimebutine Preparation Products And Raw materials
Raw materials2-AMINO-2-PHENYLBUTYRIC ACID
1-Dimethylamino-2-phenylbutan-2-yl 3,4,5-trimethoxybenzoate Trimebutine maleate DESMETHYL TRIMEBUTINE HCL Methyl syringate 2-Phenylpropyl acetate ISOBUTYL GALLATE Propyl gallate BUTYL GALLATE Isobutylparaben Syringic acid METHYL-BETA-D-GALACTOPYRANOSIDE Ethyl 3,4,5-trimethoxybenzoate Trimebutine 3-Hydroxy-4,5-dimethoxybenzoic acid Vanillyl butyl ether Methyl 3,5-dihydroxybenzoate ETHYL 3,5-DIMETHOXYBENZOATE 2-DIMETHYLAMINO-2-METHYL-1-PROPANOL

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