Mepivacaine hydrochloride

Mepivacaine hydrochloride Basic information
Product Name:Mepivacaine hydrochloride
Synonyms:Mepivacaine Hydrochloride (200 mg);Ropivacaine base Mepivacaine HCL;(1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride;1-methyl-2’,6’-pipecoloxylididehydrochloride;Mepivacaine HCl USP;2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride;2',6'-Pipecoloxylidide, 1-methyl-, monohydrochloride (6CI, 8CI);2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (9CI)
CAS:1722-62-9
MF:C15H22N2O.ClH
MW:282.81
EINECS:217-023-9
Product Categories:API;Sodium channel;Amines;Aromatics;Heterocycles;Analgesic series;Intermediates & Fine Chemicals;Pharmaceuticals;1722-62-9
Mol File:1722-62-9.mol
Mepivacaine hydrochloride Structure
Mepivacaine hydrochloride Chemical Properties
Melting point 255-257°C (dec.)
storage temp. 2-8°C
solubility H2O: soluble20mg/mL, clear
form powder
color white to beige
InChIInChI=1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H
InChIKeyRETIMRUQNCDCQB-UHFFFAOYSA-N
SMILESC1(=C(C)C=CC=C1C)NC(=O)C1CCCCN1C.Cl
CAS DataBase Reference1722-62-9(CAS DataBase Reference)
EPA Substance Registry System2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-, monohydrochloride (1722-62-9)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 22-24/25
RIDADR UN 2811 6.1 / PGIII
RTECS TK6475000
HS Code 29333990
ToxicityLD50 in mice, rats (mg/kg): 280, 500 s.c. (Aberg)
MSDS Information
Mepivacaine hydrochloride Usage And Synthesis
Chemical PropertiesWhite Solid
Usesanesthetic (local)
UsesMepivacaine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography.
UsesAn anti-inflammatory and analgesic
DefinitionChEBI: The hydrochloride salt of mepivacaine. It is used as a local anaesthetic.
Brand nameArestocaine Hydrochloride (Solvay Pharmaceuticals); Carbocaine (Hospira); Isocaine Hydrochloride(Novocol); Polocaine (AstraZeneca); Polocaine (Dentsply); Scandonest (Deproco).
Biological FunctionsMepivacaine hydrochloride (Carbocaine) is longer acting than lidocaine and has a more rapid onset of action (3–5 minutes). Topical application is not effective. It has been widely used in obstetrics, but its use has declined recently because of the early transient neurobehavioral effects it produces. Adverse reactions associated with mepivacaine are generally similar to those produced by other local anesthetics. It can be used with epinephrine or levonordefrin (dental use only).
General DescriptionPharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Mepivacaine hydrochloride is a local anesthetic that is related chemically and pharmacologically to the amide-type local anesthetics. It is often administered via local infiltration, peripheral nerve block, etc.
Biochem/physiol ActionsLocal anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.
Safety Profileskin irritant. Questionable carcinogen with
Mepivacaine hydrochloride Preparation Products And Raw materials
Preparation Products2-[[(2,6-Di(Methyl-d3)phenyl)aMino]carbonyl]-1,1-diMethyl-piperidiniuM Iodide
MEPERIDINE HYDROCHLORIDE Ropivacaine hydrochloride Methyl (R)-(+)-BUPIVACAINE HCL Bupivacaine hydrochloride N,N-Dimethylformamide Bupivacaine Levobupivacaine Donepezil Hydrochloride Mepivacaine hydrochloride Kresoxim-methyl Thiophanate-methyl BUPIVACAINE HYDROCHLORIDE, [3H]- Mepivacaine Methyl salicylate SALOR-INT L211176-1EA Methyl bromide METSULFURON METHYL

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