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| | L-2-Aminoadipic acid Basic information |
| | L-2-Aminoadipic acid Chemical Properties |
| Melting point | 203-205 °C (dec.)(lit.) | | alpha | 22 º (c=2, 5 N HCl 25 ºC) | | Boiling point | 287.44°C (rough estimate) | | density | 1.3482 (rough estimate) | | refractive index | 1.4230 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | 1N HCl: 10 mg/ml; PBS (pH 7.2): 0.5 mg/ml | | form | Solid | | pka | 2.49±0.24(Predicted) | | color | White | | Water Solubility | Soluble in 1N HCl (50 mg/ml) and water (slightly). | | BRN | 1724348 | | InChIKey | OYIFNHCXNCRBQI-BYPYZUCNSA-N | | CAS DataBase Reference | 1118-90-7(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29224999 |
| | L-2-Aminoadipic acid Usage And Synthesis |
| Chemical Properties | WHITE SOLID | | Uses | An inhibitor of ischemic glutamate release | | Uses | L-2-Aminoadipic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals. | | Definition | ChEBI: The L-enantiomer of 2-aminoadipic acid. | | General Description | L-2-Aminoadipic acid/α-aminoadipate is a gliotoxin and is a structural analog of glutamine. It is generated by the catabolism of lysine saccharopine (SAC)/pipecolic acid (PIP) pathways. | | Biochem/physiol Actions | L-2-Aminoadipic acid inhibits glutamine synthetase and γ-glutamylcysteine synthetase. It modulates glucose metabolism and is present in higher levels in diabetic patients. L-2-Aminoadipic acid plays a key role in suppressing autophagy in C2C12 myotubes. |
| | L-2-Aminoadipic acid Preparation Products And Raw materials |
| Raw materials | Hexanedioic acid, 2-[[(phenylmethoxy)carbonyl](phenylmethyl)amino]-, (S)- (9CI)-->1(3H)-Isobenzofuranone, hexahydro-, (3aR,7aS)--->Hexanedioic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, 1-(1,1-dimethylethyl) ester, (2S)--->6-Oxo-N6-[(phenylmethoxy)carbonyl]-L-lysine-->Z-AAD-OH-->BOC-L-2-AMINOADIPIC ACID-->CIS-1,2-CYCLOHEXANEDIMETHANOL-->L-2-Aminoadipamic Acid-->(S)-2-PIPERIDINONE-6-CARBOXYLIC ACID |
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