N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Basic information
Product Name:N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
Synonyms:1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl-;N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine WZ811;WZ 811 N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine;WZ 811, >=98%;N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine;WZ 811;N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE;N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine
CAS:55778-02-4
MF:C18H18N4
MW:290.36
EINECS:200-256-5
Product Categories:Inhibitors
Mol File:55778-02-4.mol
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Structure
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Chemical Properties
Melting point 192-194℃ (methanol )
Boiling point 493.2±35.0 °C(Predicted)
density 1.229±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMSO: ≥7mg/mL
pka6.55±0.10(Predicted)
form powder
color white to tan
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26
WGK Germany 3
HS Code 2933.39.6190
MSDS Information
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Usage And Synthesis
DescriptionThe CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM). It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC50 = 1.2 nM) in cells and blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM). The effectiveness of WZ811 in animals remains to be elucidated.
UsesN1,N4-di-2-Pyridinyl-1,4-benzenedimethanamine acts as an inhibitor for the chemokine receptor CXCR4.
references[1] zhan w, liang z, zhu a, et al. discovery of small molecule cxcr4 antagonists. journal of medicinal chemistry, 2007, 50(23): 5655-5664.
[2] choi w t, duggineni s, xu y, et al. drug discovery research targeting the cxc chemokine receptor 4 (cxcr4). journal of medicinal chemistry, 2011, 55(3): 977-994.
N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Preparation Products And Raw materials
BEZ235 (NVP-BEZ235, Dactolisib) Rapamycin WZ4141 RG108 PLERIXAFOR WZ8040 Entinostat WZ4141R WZ4002 WZB117 WZ3146 Bortezomib WZ4003

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