ChemicalBook Product Catalog Chemical Reagents Organic reagents Aromatic ketones 2'-Hydroxy-5'-methoxyacetophenone

2'-Hydroxy-5'-methoxyacetophenone

2'-Hydroxy-5'-methoxyacetophenone Basic information
Product Name:2'-Hydroxy-5'-methoxyacetophenone
Synonyms:5-Methoxy-2-hydroxyacetophenone;Acetophenone, 2'-hydroxy-5'-methoxy-;1-(2-HYDROXY-5-METHOXYPHENYL)ETHAN-1-ONE;1-(2-HYDROXY-5-METHOXYPHENYL)ETHANONE;2'-HYDROXY-5'-METHOXYACETOPHENONE;2-HYDROXY-5'-METHOXYACETOPHENONE;2-HYDROXY-5-METHOXYACETOPHENONE;2'-HYDROXY-5'-METHOXYACETYLPHENONE
CAS:705-15-7
MF:C9H10O3
MW:166.17
EINECS:211-882-3
Product Categories:ketone| alcohol;Aromatic Acetophenones & Derivatives (substituted);C9;Carbonyl Compounds;Ketones
Mol File:705-15-7.mol
2'-Hydroxy-5'-methoxyacetophenone Structure
2'-Hydroxy-5'-methoxyacetophenone Chemical Properties
Melting point 52 °C(lit.)
Boiling point 254.38°C (rough estimate)
density 1.1708 (rough estimate)
refractive index 1.5500 (estimate)
Fp >230 °F
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka10.65±0.18(Predicted)
form Crystalline Powder
color Yellow
BRN 1239364
InChIKeyMLIBGOFSXXWRIY-UHFFFAOYSA-N
CAS DataBase Reference705-15-7(CAS DataBase Reference)
NIST Chemistry ReferenceEthanone, 1-(2-hydroxy-5-methoxyphenyl)-(705-15-7)
Safety Information
Hazard Codes Xi
Risk Statements 37/38-41-36/37/38
Safety Statements 26-37/39-36/37/39-22
WGK Germany 3
Hazard Note Irritant
HS Code 29145090
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
2'-Hydroxy-5'-methoxyacetophenone Usage And Synthesis
Chemical Propertiesyellow crystalline powder
Uses2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols. 2-Hydroxy-5-methoxyacetophenone is also used to prepare substituted chromanone and chromone derivatives as sirtuin 2-selective inhibitors.
Preparationreparation by reaction of dimethyl sulfate on 2,5-dihydroxyacetophenone, ? with potassium carbonate in acetone at r.t. (74%) ; ? with aqueous sodium hydroxide solution at reflux (35%).
Synthesis Reference(s)Synthesis, p. 901, 1985 DOI: 10.1055/s-1985-31380
General Description2′-Hydroxy-5′-methoxyacetophenone is observed as a side reaction product of elbs persulphate oxidation of phenols.
2'-Hydroxy-5'-methoxyacetophenone Preparation Products And Raw materials
Raw materials1-(2-hydroxy-3-methoxy-phenyl)ethanone-->3-METHOXYPHENYL ACETATE-->3-Methoxyacetophenone
2',4',5'-TRIMETHOXYACETOPHENONE 4'-Methoxyacetophenone MELICOPIDINE 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE 3-Aminoacetophenone 2'-Methoxyacetophenone 4-Nitroacetophenone 2',5'-Dimethoxyacetophenone KHELLIN 2'-HYDROXY-4',5'-DIMETHOXYACETOPHENONE 2',4'-Dichloroacetophenone 2'-Hydroxy-5'-methoxyacetophenone 4'-Hydroxyacetophenone 6,7-DIMETHOXY-2,2-DIMETHYL-4-CHLOROMANONE CHLOROPHOSPHONAZO III 3-Methoxyacetophenone PIPERACETAZINE (250 MG) 3',5'-Dimethoxyacetophenone
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