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| | 2-Hydroxypropyl-β-cyclodextrin Basic information |
| | 2-Hydroxypropyl-β-cyclodextrin Chemical Properties |
| Melting point | 278 °C (dec.) | | Boiling point | 400℃ | | density | 1.05 at 20.3℃ | | refractive index | 125 ° (C=1, H2O) | | storage temp. | room temp | | solubility | H2O: 45 % (w/v) | | form | solution (clear, colorless) | | color | White to slightly yellow | | optical activity | [α]26/D +139°, c = 1 in H2O | | Water Solubility | Soluble in water. | | InChIKey | ODLHGICHYURWBS-FOSILIAISA-N | | LogP | -4 at 20℃ | | Surface tension | 63.6-65mN/m at 1g/L and 22℃ | | EPA Substance Registry System | .beta.-Cyclodextrin, 2-hydroxypropyl ethers (128446-35-5) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | GU2293332 | | TSCA | Yes | | HS Code | 29400090 | | Toxicity | mouse,LD,intravenous,> 5gm/kg (5000mg/kg),Journal of Pharmaceutical Sciences. Vol. 84, Pg. 1223, 1995. |
| | 2-Hydroxypropyl-β-cyclodextrin Usage And Synthesis |
| Chemical Properties | White to slightly yellow powder | | Chemical Properties | Hydroxypropyl betadex occurs as a white or almost white,
amorphous or crystalline powder. | | Uses | 2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin. | | Uses | enteric coating, sustained release formulations, buccal and transdermal drug delivery | | Uses | 2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis
| | Production Methods | Hydroxypropyl betadex is prepared by the treatment of an alkaline
solution of b-cyclodextrin with propylene oxide. The substitution
pattern can be influenced by varying the pH. Formation of O-6 and
O-2 substituted products is favored by high and low alkali
concentration, respectively. The mixture of products produced
may be refined by preparative chromatography. | | General Description | (2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, finds application as a formulation vehicle that is used to enhance the solubility of the drugs in aqueous solutions for the successful delivery of medical agents to biological systems. It is generally employed as a substitute for α-, β- and γ-cyclodextrins. | | Pharmaceutical Applications | Hydroxypropyl betadex has been widely investigated in pharmaceutics
and has principally been used as a solubilizer for
hydrophobic molecules in oral liquids,oral solids, parenterals,
pressurized metered dose inhalers, dry powder inhalers,
and topical formulations. It has also been shown to act as a
stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported
to show mechanical properties distinct from the pure materials.
The reported advantage of hydroxypropyl betadex over unsubstituted
b-cyclodextrin is its greater water solubility. | | Safety | The pharmaceutical toxicology of hydroxypropyl betadex has been
reviewed, and in general, the material was found to be of low
toxicity. It has been suggested that hydroxypropyl betadex may
have a synergistic toxic effect with, for example, carcinogens, by
increasing their solubility and thus bioavailability. | | storage | Store in well-closed containers. | | Regulatory Status | Included in oral and parenteral medicinal products. Included in an
injectable preparation licensed in the UK for intramuscular or
intravenous administration. |
| | 2-Hydroxypropyl-β-cyclodextrin Preparation Products And Raw materials |
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