3-Methoxyphenol

3-Methoxyphenol Basic information
Product Name:3-Methoxyphenol
Synonyms:3-Hydroxy phenyl methyl ether;3-Methoxyphenol,3-Hydroxyanisol;RESORCINOLMETA-MONOMETHYLETHER;META-METHOXYPHENOL;m-Methoxyphel;3-Methoxyphenol ,98%;3-Hydroxyanisol, Resorcinol monomethyl ether;3-Methxoyphenol
CAS:150-19-6
MF:C7H8O2
MW:124.14
EINECS:205-754-6
Product Categories:Building Blocks;C6 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Phenols;Aromatic Ethers;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;bc0001
Mol File:150-19-6.mol
3-Methoxyphenol Structure
3-Methoxyphenol Chemical Properties
Melting point -17 °C
Boiling point 113-115 °C/5 mmHg (lit.)
density 1.131 g/mL at 25 °C (lit.)
refractive index n20/D 1.552(lit.)
Fp >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Liquid
pka9.65(at 25℃)
color Clear pink-reddish to brown
Odorat 1.00?%?in?dipropylene glycol. phenolic
Water Solubility slightly soluble
BRN 1209898
InChIKeyASHGTJPOSUFTGB-UHFFFAOYSA-N
LogP1.340
CAS DataBase Reference150-19-6(CAS DataBase Reference)
NIST Chemistry Reference3-Methoxyphenol(150-19-6)
EPA Substance Registry SystemPhenol, 3-methoxy- (150-19-6)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-36/38-41-36/37/38-43-36-22
Safety Statements 26-36/37/39-46-37/39-24/25
RIDADR UN 2810 6.1/PG 3
WGK Germany 3
RTECS SL7524000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29095090
Toxicityhuman,TCLo,inhalation,230ug/m3/22W (0.23mg/m3),BEHAVIORAL: IRRITABILITYBEHAVIORAL: MUSCLE WEAKNESSBEHAVIORAL: HEADACHE,Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 37(3), Pg. 108, 1972.
MSDS Information
ProviderLanguage
3-Hydroxyanisole English
SigmaAldrich English
ACROS English
ALFA English
3-Methoxyphenol Usage And Synthesis
Chemical PropertiesClear pink red liquid
UsesA phenol derivative, 3-Methoxyphenol can be used as catalysts and as building blocks in synthesis of organic compounds such as antioxidants.
Uses3-Methoxyphenol may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.
DefinitionChEBI: 3-methoxyphenol is a member of the class of phenols that is phenol having a methoxy-substituent at the 3-position. It is a member of phenols and a monomethoxybenzene. It derives from a resorcinol.
Preparationsynthesis of 3-methoxyphenol: The 1 mole of resorcinol is treated rapidly with stirring, in a three-necked flask provided with a reflux condenser, stirrer, internal thermometer, and dropping funnel, with 1.25 mole of 10% sodium hydroxide. With vigorous stirring, 1 mole of dimethyl sulfate is added in such a way that the temperature remains below 40° C (water cooling). To complete the reaction and to destroy unchanged dimethyl sulfate, the mixture is then heated for 30 min on a boiling water bath. After cooling, the organic layer is separated off and the aqueous solution is extracted several times with ether. The combined organic phases are washed with dilute sodium carbonate and then with water, dried with calcium chloride, and fractionated. Unchanged resorcinol can be recovered by acidifying the aqueous reaction solution and the wash water and extracting them with ether. The yield of 3-methoxyphenol is 50%, b.p. 113-115 °C/5 mm; b.p. 144°C/25mm; n20/D 1.552; d=1.131 g/mL at 25 °C.
Organicum. Practical Handbook of Organic Chemistry, by Heinz Becker, Werner Berger and Günter Domschke, Addison-Wesley Pub. Co, 206-207, (1973)
General Description3-Methoxyphenol is a phenolic aroma compound typically present in food and beverage products.
Safety ProfilePoison by ingestion and intraperitoneal routes. Moderately toxic by skin contact. Human systemic effects by inhalation: muscle weakness, headache, and irritabdtty. Human female reproductive effects by inhalation: menstrual cycle changes and dsorders. A severe eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes. See also ETHERS.
2,6-Dimethoxyphenol 4-((1S)-1-AMINOPROPYL)-2-BROMO-6-METHOXYPHENOL 3,4-dihydro-5,6,7-trimethoxy-2-naphthoic acid 2-[(1H-1,2,3-BENZOTRIAZOL-4-YLAMINO)METHYL]-6-METHOXYPHENOL 4-((1S)-1-AMINOBUTYL)-3-METHOXYPHENOL METHOXYPHENOL, PARA-(SG) 4-((2R)PYRROLIDIN-2-YL)-6-FLUORO-2-METHOXYPHENOL 2,2'-Dihydroxy-4-methoxybenzophenone 4-((1S)-1-AMINO-2,2,2-TRIFLUOROETHYL)-3-METHOXYPHENOL 4-((2R)PYRROLIDIN-2-YL)-2-IODO-6-METHOXYPHENOL 4-((1S)-1-AMINO-2,2,2-TRIFLUOROETHYL)-2-BROMO-6-METHOXYPHENOL 3-Hydroxyphenyl acetate 4-((1S)AMINOCYCLOPROPYLMETHYL)-3-METHOXYPHENOL 3-Fluoro-4-(trifluoromethoxy)phenol 4-((1S)-1-AMINOETHYL)-2-IODO-6-METHOXYPHENOL 3-chloro-5-methoxyphenol 3,3'-ETHYLENEDIOXYDIPHENOL 4-((1S)AMINOCYCLOPROPYLMETHYL)-2-IODO-6-METHOXYPHENOL

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