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N-Acetyl-L-glutamic acid

N-Acetyl-L-glutamic acid Basic information
Product Name:N-Acetyl-L-glutamic acid
Synonyms:acetylglutamicacid;L-Glutamic acid, N-acetyl-;l-glutamicaci;N-ALPHA-ACETYL-L-GLUTAMIC ACID;N-AC-L-GLU;N-ACETYL-L-GLU;N-ACETYL-L-GLUTAMIC ACID;ACETYL-L-GLUTAMIC ACID
CAS:1188-37-0
MF:C7H11NO5
MW:189.17
EINECS:214-708-4
Product Categories:Glutamic acid [Glu, E];Ac-Amino Acids;Amino Acid Derivatives;Amino Acids;Amino Acids (N-Protected);Biochemistry;Amino Acid Derivatives;Glutamic Acid;Peptide Synthesis;amino acid;amino;1188-37-0
Mol File:1188-37-0.mol
N-Acetyl-L-glutamic acid Structure
N-Acetyl-L-glutamic acid Chemical Properties
Melting point 194-196 °C(lit.)
alpha -16 º (c=1, water)
Boiling point 324.41°C (rough estimate)
density 1.4119 (rough estimate)
FEMA 4752 | N-ACETYL GLUTAMATE
refractive index -15 ° (C=1, H2O)
storage temp. 2-8°C
solubility 36g/l (Lit.)
form Solid
pka3.45±0.10(Predicted)
color White
optical activity[α]22/D 15.6°, c = 1 in H2O
Water Solubility 2.7 g/100 mL (20 ºC)
BRN 1727473
LogP-2.131 (est)
CAS DataBase Reference1188-37-0(CAS DataBase Reference)
NIST Chemistry ReferenceN-acetyl-l-glutamic acid(1188-37-0)
EPA Substance Registry SystemL-Glutamic acid, N-acetyl- (1188-37-0)
Safety Information
Safety Statements 24/25
WGK Germany 2
RTECS LZ9725000
TSCA Yes
HS Code 29241900
MSDS Information
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N-Acetyl-L-glutamic acid English
ACROS English
SigmaAldrich English
ALFA English
N-Acetyl-L-glutamic acid Usage And Synthesis
Chemical Propertieswhite crystalline powder
UsesN-Acetyl-L-glutamic Acid is the N-Acetyl analogue of the non-essential amino acid, L-glutamic acid (G596960). N-Acetyl-L-glutamic Acid activates carbamoyl phosphate synthetase in the urea cycle.
UsesSubstrate for acetylglutamate kinase. Inhibitor of N-acetyl-L-glutamate synthetase
UsesN-Acetyl-L-glutamic acid is used as pharmaceutical intermediates.
DefinitionChEBI: N-acetyl-L-glutamic acid is an N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group. It has a role as a Saccharomyces cerevisiae metabolite and a human metabolite. It is a N-acetyl-L-amino acid and a N-acyl-L-glutamic acid. It is functionally related to a L-glutamic acid. It is a conjugate acid of a N-acetyl-L-glutamate(1-).
Purification MethodsA likely impurity is glutamic acid. Crystallise it from boiling water. It inhibits N-acetyl-L-glutamate synthase. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1948 1961, Shigesada & Tatibana Eur J Biochem 84 285 1978, Coude Biochem Biophys Res Commun 102 1016 1981, Beilstein 4 IV 3047.]
N-Acetyl-L-glutamic acid Preparation Products And Raw materials
H-GLU-GLU-OH N-(p-Aminobenzoyl)glutamic acid P-NITROBENZOYL-L-GLUTAMIC ACID Z-ALA-GLU-OH prolylglutamic acid H-GAMMA-GLU-GLU-OH H-VAL-GLU-OH BZ-GLU-OH H-ALA-GLU-OH H-PHE-GLU-OH N-Acetyl-L-glutamic acid H-GLU-GLU-GLU-OH Aminopterin Calcium folinate H-TRP-GLU-OH H-GLU-TYR-GLU-OH H-LYS-GLU-OH 3',5'-DICHLOROFOLIC ACID
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