ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Other amino acid derivatives DL-ETHIONINE

DL-ETHIONINE

DL-ETHIONINE Basic information
Product Name:DL-ETHIONINE
Synonyms:DL-ETHIONINE;DL-2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID;S-ETHYL-DL-HOMOCYSTEINE;2-AMINO-4-ETHYLMERCAPTOBUTYRIC ACID;2-AMINO-4-(ETHYLTHIO) BUTYRIC ACID;(.+/-.)-Ethionine;(+-)-ethionine;)-Ethionine
CAS:67-21-0
MF:C6H13NO2S
MW:163.24
EINECS:200-647-0
Product Categories:Amino Acids 13C, 2H, 15N;Amino acids methyl、ethyl、t-butyl series;Amino Acids & Derivatives;Sulfur & Selenium Compounds;Sulphur Derivatives
Mol File:67-21-0.mol
DL-ETHIONINE Structure
DL-ETHIONINE Chemical Properties
Melting point 265-268 °C
alpha [α]D20 0±0.5° (c=5, dil. HCl)
Boiling point 310℃
density 1.164
refractive index 1.5500 (estimate)
Fp 142℃
storage temp. -20°C
solubility Methanol (Slightly, Heated), Water (Slightly)
pka2.23±0.10(Predicted)
form Crystalline Powder or Flakes
color White to off-white
Water Solubility Soluble in water.
Merck 14,3738
BRN 1722529
CAS DataBase Reference67-21-0(CAS DataBase Reference)
EPA Substance Registry SystemS-Ethylhomocysteine (67-21-0)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
RTECS ES6825200
TSCA Yes
HS Code 29309090
ToxicityThe Sethyl analog of methionine. It is a carcinogen and hepatotoxic agent once proposed as an antineoplastic agent. It inhibits the incorporation of methionine and glycine into proteins and substitutes for methionine in transmethylation reactions, the ethyl group appearing in the products in place of the methyl groups of methionine (e.g., ethylcholine is formed instead of choline). Ethionine is currently used only as an experimental compound in studies of hepatotoxicity and methionine metabolism and nutrition.
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
DL-ETHIONINE Usage And Synthesis
Chemical PropertiesOff-White Solid
Usesantineoplastic; inhibitor DNA methylation
UsesDL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. It is also used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.
DefinitionChEBI: A non-proteinogenic alpha-amino acid that is methionine in which the S-methyl group is replaced by an S-ethyl group.
General DescriptionWhite crystalline flakes.
Air & Water ReactionsSlightly soluble in water.
Reactivity ProfileA synthetic thio-substituted amino acid.
Health HazardACUTE/CHRONIC HAZARDS: When heated to decomposition DL-ETHIONINE emits toxic fumes of NOx and SOx.
Fire HazardFlash point data for DL-ETHIONINE are not available; however, DL-ETHIONINE is probably combustible.
Biochem/physiol ActionsDL-Ethionine is a racemic mixture of the anti-methylation agent L-Ethionine and its enantiomer D-Ethionine. DL-Ethionine is used as a dietary supplement to accelerate cholangiocarcinogenesis in vivo. DL-Ethionine is used to induce oxidative stress in liver to study the levels and activities of anti-oxidative enzymes and compounds such as glutathione.
Safety ProfileMddly toxic by ingestion and intraperitoneal routes. Suspected carcinogen with experimental carcinogenic and tumorigenic data. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and NOx.
DL-ETHIONINE Preparation Products And Raw materials
Preparation ProductsL-ETHIONINE-->DL-ETHIONINE SULFONE-->Homocysteine, S-ethyl-N-[(phenylmethoxy)carbonyl]-
L-BUTHIONINE SULFOXIDE D-ETHIONINE L-BUTHIONINE S-Adenosyl-L-methionine S-ADENOSYL-L-METHIONINE IODIDE SALT D,L-BUTHIONINE DL-ETHIONINE SULFONE N-FORMYL-DL-ETHIONINE 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE S-ADENOSYL-L-METHIONINE CHLORIDE SALT BOC-HOCYS(BZL)-OH DNP-DL-ETHIONINE SULFONE N-ACETYL-DL-ETHIONINE CHOLINE DEFICIENT DIET WITH DL ETHIONINE D-CYSTATHIONINE DL-ETHIONINE SULFOXIDE S-BENZYL-DL-HOMOCYSTEINE L-ETHIONINE
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