Salinomycin

Salinomycin Basic information
Chemical Properties Uses production method
Product Name:Salinomycin
Synonyms:SALINOMYCIN SODIUM SALT 2.5-HYDRATE;SALINOMYCIN SV SODIUM SALT 2,5-HYDRATE;Salinomycin hydrate monosodium salt;Salinomycin sodium premix;Salinomycin, monosodium salt;salinomycin monosodium salt hydrate;Salinomycin-Natrium;(2R)-2-[(5S,6R)-6-[(2S,3S,4S,6R)-6-[(2S,5R,7S,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid
CAS:55721-31-8
MF:C42H71NaO12
MW:791
EINECS:611-309-0
Product Categories:Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;S;SA - SM;Organics;Antibiotics;BactericidalAntibiotics;Chemical Structure;OthersAlphabetic;Principle
Mol File:55721-31-8.mol
Salinomycin Structure
Salinomycin Chemical Properties
Melting point 140-142°
alpha D25 -37° (c = 1 in ethanol)
storage temp. APPROX 4°C
solubility Soluble in DMSO.
form neat
color White
Merck 13,8415
BRN 4901827
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR 2811
WGK Germany 3
HazardClass 6.1
PackingGroup III
MSDS Information
Salinomycin Usage And Synthesis
Chemical PropertiesWhite or light yellow crystalline powder, slight specific smell, melting point 140-142 ℃. Soluble in acetone, chloroform, benzene, ethyl acetate, diethyl ether and methanol, almost insoluble in water. Rats by oral LD5070-100mg/kg, mice orally LD5050mg/kg, chicken LD50150mg/kg.
UsesSalinomycin is safe and effective coccidiostat,which has inhibitory effect on most Gram-positive bacteria ,it also has effect on chicken coccidiosis, soft Ehrlich, Ehrlich poison, giant Ehrlich, Ehrlich and heap-shaped ball Harrington insects. It can be used for chicken feed, the amount is 50-60g/t,it should be stopped during laying period, the period is 5 days. Equine animals are hanged, it causes death after use; and it is banned using it with tiamulin, oleandomycin simultaneously.
The above information is edited by the chemicalbook of Tian Ye.
production methodIt is produced by fermentation of white Streptomyces (Streptomyces albus).
DescriptionSalinomycin Na (55721-31-8) is a polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma.1?Salinomycin Na displays selective toxicity for cancer stem cells.1?Induces rapid mitochondrial hyperpolarization.2?Induces selective cytotoxicity to MCF-7 mammosphere cells via the hedgehog signaling pathway.3?Salinomycin Na reduces doxorubicin resistance of breast tumor cells by inhibiting drug efflux pump expression and activity.4?Kills cancer stem cells by sequestering iron.5
Chemical PropertiesBrown Solid
UsesSalinomycin is an ionophore agent.
UsesSalinomycin sodium is prepared from salinomycin taking advantage of the acidic carboxylic acid which ionises and readily forms the salt in sodium hydroxide solutions. The sodium salt is the preferred formulation in animals to prevent coccidiosis and to promote growth. Salinomycin has a high affinity for monovalent cations, particularly potassium. Recently, salinomycin has been shown to inhibit cancer stem cells.
References1) Gupta?et al. (2009),?Identification of selective inhibitors of cancer stem cells by high-throughput screening; Cell,?138?645 2) Manago?et al. (2015),?Early effects of the antineoplastic agent salinomycin on mitochondrial function; Cell Death Dis.,?6?e1930 3) Fu?et al. (2016),?Salinomycin induces selective cytotoxicity to MCF-7 mammosphere cells through targeting the Hedgehog signaling pathway;?Oncol. Rep.,?35?912 4)?Kim?et al.?(2015), Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin;?Mol. Med. Rep.,?12(2)?1898 5) Mai et al. (2017)?Salinomycin kills cancer stem cells by sequestering iron in lysosomes; Nat. Chem.,?9?1025
Salinomycin Preparation Products And Raw materials
Raw materialsAmmonium L-tartrate
CIS-2,5-BISHYDROXYMETHYL-TETRAHYDROFURAN SODIUM SALINOMYCIN Salinomycin benzyl ester 1-(2-METHOXYETHOXY)-2-METHYL-2-PROPANOL Granulose (Z)-14-METHYL-8-HEXADECEN-1-AL SALINOMYCIN PREMIX Salinomycin (R)-(-)-3-HYDROXYBUTYRIC ACID, SODIUM SALT 3-HYDROXYHEXADECANOIC ACID CIS-2-METHYL-7-OCTADECENE Sodium Palmitate 4,4-DIMETHOXY-1-BUTENE (Tetrahydro-pyran-2-yl)acetic acid 3-HYDROXYOCTADECANOIC ACID 4-ISOBUTOXY-2-BUTANONE Granulose salinomyclin Salinomycin sodium (850u/mg up)

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