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| | Ethyl trichloroacetate Basic information |
| | Ethyl trichloroacetate Chemical Properties |
| | Ethyl trichloroacetate Usage And Synthesis |
| Chemical Properties | Colorless liquid with a menthol-like odor. It is miscible with ethanol, ether and benzene, but insoluble in water. | | Uses | Ethyl trichloroacetate was used in the synthesis of dichlorocarbon precursor, phenyl(trichloromethyl)methyl. | | Application | Ethyl trichloroacetate can be used as solvent, organic synthesis, perfume and pharmaceutical intermediates. | | Preparation | Ethyl trichloroacetate is synthesized from trichloroacetic acid and ethyl alcohol by the esterification reaction.
synthesis steps: Trichloroacetic acid(TCA), anhydrous ethyl alcohol and sulfuric acid are heated together and refluxed for 6 h. After cooling, the ester layer is separated by pouring into water, neutralized with 5-10% sodium carbonate solution, washed with water and dried overnight with anhydrous calcium chloride. After filtration, distillation was carried out to obtain the finished product. Yield 75%. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 46, p. 3519, 1981 DOI: 10.1021/jo00330a028 | | General Description | Ethyl trichloroacetate undergoes atom-transfer radical addition reaction with styrene catalyzed by the Ru-pentamethylcyclopentadienyl complexes. | | Purification Methods | Shake the ester with saturated aqueous Na2CO3 (three times), aqueous 50% CaCl2 (three times), saturated aqueous NaCl (twice), then distil over CaCl2 and redistil it under reduced pressure. [Beilstein 2 IV 514.] |
| | Ethyl trichloroacetate Preparation Products And Raw materials |
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