Dimethylamine hydrochloride

Dimethylamine hydrochloride Basic information

Product Name:	Dimethylamine hydrochloride
Synonyms:	hydrochloricaciddimethylamine;Methanamine,N-methyl-,hydrochloride;n-methylmethanaminehydrochloride;n-methyl-methanaminhydrochloride;MethanaMine,N-Methyl-, hydrochloride (1:1);Dimethylamine hydrochloride≥ 98% (Assay, dry basis);Dimethylammonium chloride Msynthplus;Dimethylamine Hydrochloride(Metformin Impurity F)
CAS:	506-59-2
MF:	C2H8ClN
MW:	81.54
EINECS:	208-046-5
Product Categories:	amine series;Amine Salts;Nitrogen Compounds;Organic Building Blocks;506-59-2
Mol File:	506-59-2.mol

Dimethylamine hydrochloride Chemical Properties

Melting point	170-173 °C(lit.)
Boiling point	95.79°C (rough estimate)
density	0.8949 (rough estimate)
vapor pressure	<0.1 hPa (25 °C)
refractive index	1.4202 (estimate)
storage temp.	Store below +30°C.
solubility	H2O: soluble0.5g/10 mL
form	Crystalline Powder or Crystals
color	White to off-white
PH	5 (100g/l, H2O, 20℃)
Water Solubility	3000 g/L (20 ºC)
Sensitive	Hygroscopic
Merck	14,3228
BRN	3589311
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	IQDGSYLLQPDQDV-UHFFFAOYSA-N
LogP	-3.28
CAS DataBase Reference	506-59-2(CAS DataBase Reference)
EPA Substance Registry System	Methanamine, N-methyl-, hydrochloride (506-59-2)

Safety Information

Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36/37-37/39-36
WGK Germany	1
RTECS	IQ0220000
F	3-9
TSCA	Yes
HS Code	29211190
Toxicity	LD50 in mice (g/kg): 1.21 i.v., 2.00 s.c. (Hazard); LC50 in mice (ppm): 7650 (48 hr), 4725 (14 day); in rats (ppm): 4540 (6 hr) (Steinhagen)

MSDS Information

Provider	Language
Dimethylammonium chloride	English
SigmaAldrich	English
ALFA	English

Dimethylamine hydrochloride Usage And Synthesis

Chemical Properties	White, foliage-like crystals with a melting point of 171°C. Highly soluble in water, soluble in alcohol and chloroform, and insoluble in ether. Exhibits deliquescence.
Uses	Dimethylamine hydrochloride is a precursor to several industrially significant compounds.
Uses	As accelerator in vulcanizing rubber, tanning, manufacture of detergent soaps, or attracting boll weevils to exterminate them. As reagent for Mg.
Uses	Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.
Application	Dimethylamine hydrochloride serves as a foundational material for organic synthesis and is utilized as a catalyst and magnesium reagent in acetylation analysis. It has been used in producing hexamethylmelamine-methyl-14C and in preparing standard solutions of methylamine (MA), dimethylamine (DMA), trimethylamine (TMA), and trimethylamine-N-oxide (TMAO) to assess the presence of methylamines and trimethylamine-N-oxide in particulate matter.
Preparation	Dimethylamine hydrochloride is obtained from the salt formation of dimethylamine and hydrochloric acid.
Flammability and Explosibility	Nonflammable
Purification Methods	Crystallise the salt from hot CHCl3 or absolute EtOH. It also recrystallises from MeOH/ether solution. Dry it in a vacuum desiccator over H2SO4, then P2O5. Hygroscopic. [Beilstein 4 IV 132.]

Dimethylamine hydrochloride Preparation Products And Raw materials

Raw materials

Dimethylamine

Preparation Products

Ethacrynic acid-->FUSARIC ACID-->5-BUTYLPYRIDINE-2-CARBONITRILE-->(3S)-(-)-3-(DIMETHYLAMINO)PYRROLIDINE-->Ondansetron-->2-METHYL-4-TRIFLUOROMETHYL-NICOTINIC ACID-->2-Chloro-N,N-dimethylacetamide-->3-AMINO-N,N-DIMETHYL-BENZENESULFONAMIDE-->(3R)-(+)-3-(DIMETHYLAMINO)PYRROLIDINE-->DIMETHYLAMINOACETYL CHLORIDE HYDROCHLORIDE-->N,N-Dimethylpiperidin-4-amine-->N,N-Dimethyloctylamine-->Dimethylsulfamoyl chloride-->1,1,3,3-Tetramethylurea-->N-NITROSODIMETHYLAMINE-->3-(1-dimethylamino-2-methyl-pentan-3-yl)phenol-->CHLORODIMETHYLAMINE-->ETHYL N,N-DIMETHYLOXAMATE-->trans 4-DiMethylaMinocrotonic Acid Methyl Ester

N-(3-Chloro-2-hydroxypropyl)dimethylamine, hydrochloride salt 4'-Chloroacetoacetanilide N-METHYL-N-PHENYLCARBAMOYL CHLORIDE N-(4-CHLORO-4-METHYLPENTYL)-N,N-DIMETHYLAMINE HYDROCHLORIDE, TECH (α-3-Hydroxyphenyl)-ethyl dimethylamine hydrochloride N-[2-amino-4-(piperidin-1-ylsulfonyl)phenyl]-N,N-dimethylamine hydrochloride N-[4-amino-3-(trifluoromethyl)phenyl]-N,N-dimethylamine hydrochloride 4-CHLOROBENZANILIDE Topotecan hydrochloride DIMETHYLAMINE HYDROCHLORIDE, [14C] N-[2-amino-1-(3-methylthien-2-yl)ethyl]-N,N-dimethylamine hydrochloride 3-CHLORODIPHENYLAMINE N-[1-(aminomethyl)-4-methylcyclohexyl]-N,N-dimethylamine hydrochloride Aminodiphenylmethane hydrochloride N-(4-CHLORO-PHENYL)-OXALAMIC ACID ETHYL ESTER Minocycline hydrochloride N-(2-amino-1-methylethyl)-N,N-dimethylamine hydrochloride N-[4-[2-AMINO-1-(1H-INDOL-3-YL)ETHYL]PHENYL]-N,N-DIMETHYLAMINE HYDROCHLORIDE Dimethylamine Hcl

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Dimethylamine hydrochloride

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