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| | Thymidine Basic information |
| | Thymidine Chemical Properties |
| Melting point | 186-188 °C(lit.) | | alpha | 18.6 º (c=3, H2O) | | Boiling point | 385.05°C (rough estimate) | | density | 1.3129 (rough estimate) | | refractive index | 33 ° (C=1, 1mol/L NaOH) | | storage temp. | 2-8°C | | solubility | Acetone, DMSO (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly, Heated), P | | pka | pK1:9.79;pK2:12.85 (25°C) | | form | Crystalline Powder | | color | White to almost white | | optical activity | [α]20/D +19±1°, c = 1% in H2O | | Water Solubility | SOLUBLE | | Merck | 14,9397 | | BRN | 89285 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChIKey | IQFYYKKMVGJFEH-XLPZGREQSA-N | | LogP | -0.930 | | CAS DataBase Reference | 50-89-5(CAS DataBase Reference) | | NIST Chemistry Reference | Thymidine(50-89-5) | | EPA Substance Registry System | Thymidine (50-89-5) |
| | Thymidine Usage And Synthesis |
| Description | Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. In cell biology it is used to synchronize the cells in G1/early S phase. | | Chemical Properties | White needle crystal, soluble in methanol, ethanol, DMSO and other organic solvents. | | Uses | Constituent of deoxyribonucleic acid. The nucleoside (deoxyriboside) of thymine. Occurs in DNA. It is a nucleoside consisting of one thymine molecule linked to ad-doxyribose sugar molecule. | | Uses | Thymidine is used in the syntheses of active pharmaceutical ingredient such as zidovudine. It also pairs with deoxyadenosine in double-stranded deoxyribonucleic acid. It is used to synchronize the cells in G1/early S phase in cell biology. | | Definition | The NUCLEOSIDE formed when thymine is linked to
D-ribose by a β-glycosidic bond. | | Definition | ChEBI: Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a thymine. It is an enantiomer of a telbivudine. | | General Description | Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine. | | Biochem/physiol Actions | Thymidine is useful in cell synchronization during S-phase. In the salvage pathway of pyrimidines, pyrimidine phosphorylase reversibly converts thymine to thymidine. | | Safety Profile | Moderately toxic by
intraperitoneal route. An experimental
teratogen. Experimental reproductive
effects. Human mutation data reported.
When heated to decomposition it emits
toxic fumes of NOx. | | Purification Methods | Crystallise -thymidine from ethyl acetate, MeOH/Et2O (m 188o) or H2O (as 2H2O m 189o). It is soluble in water and hot organic solvents. The picrate has m 230o (from EtOH). |
| | Thymidine Preparation Products And Raw materials |
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