1-METHYLURIC ACID

1-METHYLURIC ACID Basic information
Product Name:1-METHYLURIC ACID
Synonyms:1-METHYLURIC ACID;1-METHYL-2,6,8-TRIHYDROXYPURINE;7,9-dihydro-1-methyl-1H-purine-2,6,8(3H)-trione;1-methyl-7,9-dihydro-3H-purine-2,6,8-trione;1-Methyluric acid ,98%;1-Methyluric acid,1-Methyl-2,6,8-trihydroxypurine;1MUA;1-U
CAS:708-79-2
MF:C6H6N4O3
MW:182.14
EINECS:211-905-7
Product Categories:Bases & Related Reagents;Heterocycles;Metabolites & Impurities;Nucleotides;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Purines
Mol File:708-79-2.mol
1-METHYLURIC ACID Structure
1-METHYLURIC ACID Chemical Properties
Melting point >325°C
Boiling point 315.51°C (rough estimate)
density 1.5283 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. Refrigerator
solubility Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated, Sonicated)
pka5.60±0.50(Predicted)
form Solid
color Pale Yellow to Pale Brown
Water Solubility 1.585g/L(temperature not stated)
BRN 195190
Safety Information
WGK Germany 3
HS Code 29242990
MSDS Information
ProviderLanguage
SigmaAldrich English
1-METHYLURIC ACID Usage And Synthesis
Chemical PropertiesWhite to Off-White Solid
Uses1-Methyluric acid, a metabolite of Theophylline, has been used:
for the determination of uric acid in stool samples by liquid chromatography and tandem mass spectrometry
in turbidimetric assay of synthetic urine samples
as a substrate for CYP1A2(cytochrome P450 family 1 subfamily A member 2) assay
DefinitionChEBI: An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by a methyl group at N-1. It is one of the metabolites of caffeine found in human urine.
Biochem/physiol Actions1-Methyluric acid (1-U) is a major metabolite of caffeine and theophylline with antioxidant activity that protects molecules such as low density lipoproteins (LDL) from oxidative modifications. 1-Methyluric acid may be used in studies aimed at differentiating the activities of caffeine and theophylline metabolites.
Purification MethodsRecrystallise it from H2O. Its solubility at 17.5o is 1g in 353mL of H2O. [Bergmann & Dikstein J Am Chem Soc 77 691 1955.] It has UV: max at 231 and 283nm (pH 3), and 217.5 and 292.5nm (pH >12) [Johnson Biochem J 5 133 1952]. [Beilstein 26 II 299, 26 III/IV 2621.]
1-METHYLURIC ACID Preparation Products And Raw materials
Theanine Chlorotrimethylsilane Methylcyclohexane p-Toluic acid Tetramethyl uric acid 9-METHYLURIC ACID 1-METHYLURIC ACID-D3 1,3-Dimethyluric acid 1,7-DIMETHYLURIC ACID TETRAMETHYLURIC ACID 1-METHYLURIC ACID 3-METHYLURIC ACID 1,3,7-TRIMETHYLURIC ACID [7-CD3]-1,3,7-Trimethyluric Acid 1,9-DIMETHYL-2,6,8-TRIHYDROXYPURINE 7-METHYLURIC ACID Uric acid

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