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| | viomycin Basic information |
| Product Name: | viomycin | | Synonyms: | viomycin;FLORIMYCIN;Coliomycin;Tuberactinomycin B;Vinacetin A;Vioactane;Viocin;(S)-3,6-Diamino-N-((3S,9S,12S,15S,Z)3((2R,4S)-6-amino-4-hydroxy-1,2,3,4-tetrahydropyridin-2-yl)-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-6-(ureidomethylene)-1,4,7,10,13-pentaazacyclohexadecan-15-yl)hexanamidedisulfate | | CAS: | 32988-50-4 | | MF: | C25H43N13O10 | | MW: | 685.7 | | EINECS: | 251-323-0 | | Product Categories: | | | Mol File: | 32988-50-4.mol |  |
| | viomycin Chemical Properties |
| Melting point | 280 °C | | Boiling point | 695.81°C (rough estimate) | | density | 1.3613 (rough estimate) | | refractive index | 1.6700 (estimate) | | storage temp. | Store at -20°C | | solubility | Water (Slightly) | | form | Powder | | pka | pKa 8.2 (Uncertain);10.3 (Uncertain) | | Water Solubility | Soluble to 75 mM in water | | Stability: | Hygroscopic |
| | viomycin Usage And Synthesis |
| Originator | Vinactane,Ciba,US ,1953 | | Uses | Viomycin is a basic peptide antibiotic, which is an effective agent against multidrug-resistant tuberculosis. | | Definition | ChEBI: A cyclic peptide antibiotic produced by the actinomycete Streptomyces puniceus, used in the treatment of tuberculosis. | | Indications | Viomycin is a complex polypeptide antibiotic that is active
against MDR strains of tuberculosis. Cross-resistance
between viomycin and kanamycin is less frequent
than between viomycin and capreomycin. | | Manufacturing Process | Viomycin is produced by inoculating a nutrient medium with a viable strain of
the organism Actinomyces vinaceus. A method for the production of viomycin
is set forth in US Patent 2,663,445 comprising inoculating a medium
containing soy peptone, beef extract, dextrose, sodium chloride and a silicone
antifoaming agent with a spore suspension of Actinomyces vinaceus and
incubating the inoculated medium for 120 hours at a temperature of 26°C
while passing sterile air through the medium at a rate of 500 ml per liter of
medium per minute. | | Brand name | Viocin
Sulfate (Pfizer). | | Therapeutic Function | Antitubercular | | Biological Activity | Member of the tuberactinomycin family of antibiotics . Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans -cleavage of the Neurospora VS ribozyme. |
| | viomycin Preparation Products And Raw materials |
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