Sodium pentachlorophenolate

Sodium pentachlorophenolate Basic information
Product Name:Sodium pentachlorophenolate
Synonyms:weedbeads;witophenn;Pentachlorophenolsodium;PENTACHLOROPHENOL SODIUM SALT;Sodium pentaehlorophenol;SODIUM PENTACHLOROPHENATE;SODIUM PENTACHLOROPHENOL;SODIUM PENTACHLOROPHENOLATE
CAS:131-52-2
MF:C6Cl5NaO
MW:288.32
EINECS:205-025-2
Product Categories:Organics;MolluscicidesOrganic Building Blocks;Oxygen Compounds;Pesticides;Pesticides&Metabolites;Phenols
Mol File:131-52-2.mol
Sodium pentachlorophenolate Structure
Sodium pentachlorophenolate Chemical Properties
Melting point >300°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color Off-White to Pale Purple
CAS DataBase Reference131-52-2(CAS DataBase Reference)
EPA Substance Registry SystemSodium pentachlorophenate (131-52-2)
Safety Information
Hazard Codes T+,N
Risk Statements 24/25-26-36/37/38-40-50/53
Safety Statements 1/2-22-36/37-45-61-60-52-28
RIDADR 2567
RTECS SM6490000
HazardClass 6.1(a)
PackingGroup II
HS Code 29081990
Hazardous Substances Data131-52-2(Hazardous Substances Data)
ToxicityLD50 oral in rabbit: 328mg/kg
MSDS Information
Sodium pentachlorophenolate Usage And Synthesis
DescriptionPentachlorophenol (PCP) can be found in two forms: pentachlorophenol itself or as the sodium salt of pentachlorophenol (NaPCP). These two forms have some different physical properties, but are expected to have similar toxic effects. PCP is a synthetic substance, made from other chemicals, and does not occur naturally in the environment. Although PCP was first synthesized in 1841, it was not produced commercially until 1936. It has since been registered for use as an insecticide, fungicide, herbicide, algicide, and disinfectant. By 1967, PCP and its sodium salt, NaPCP, were used extensively in industry and agriculture, due in large part to the solubility of PCP in organic solvents and of NaPCP in water. In 1977, both were listed together as the second most heavily used pesticide in the United States.
Chemical PropertiesSodium pentachlorophenate is a crystalline solid. Phenolic odor.
Chemical PropertiesWhite or tan powder. Soluble in water, ethanol, and acetone; insoluble in benzene.
UsesFungicide; herbicide; slimicide; fermentation disinfectant, especially in finishes and papers.
UsesPCP and its water soluble salt, NaPCP, are commercially produced organochlorine compounds used primarily as the preservatives of wood and wood products, and secondarily as herbicides, insecticides, fungicides, molluscicides, and bactericides.
General DescriptionSodium pentachlorophenolate is a white or tan, powdered solid. Sodium pentachlorophenolate is soluble in water and may burn, but Sodium pentachlorophenolate is not easily ignited. Sodium pentachlorophenolate may be toxic by ingestion, inhalation and skin absorption. Sodium pentachlorophenolate is used as a fungicide, herbicide and as a disinfectant.
Air & Water ReactionsSoluble in water.
Reactivity ProfileSodium pentachlorophenolate is incompatible with strong oxidizing agents.
HazardToxic by ingestion, inhalation; skin irritant.
Health HazardExposure can cause irritation of eyes, nose and throat. May cause weakness, excessive sweating, headache, dizziness, nausea, vomiting, and difficulty in breathing.
Fire HazardSpecial Hazards of Combustion Products: Irritating vapors and toxic gases, such as hydrogen chloride, polychlorodibenzodioxins and carbon monoxide, may be formed when involved in fire.
Safety ProfilePoison by ingestion, inhalation, skin contact, intravenous, intraperitoneal, subcutaneous, and intratracheal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland Na2O. See also CHLOROPHENOLS.
Potential ExposureUses include: wood preservative; as a fungicide in water-based latex paints; preservation of cellulose products, textiles, adhesives, leather, pulp, paper, and industrial waste systems; a contact and preemergence herbicide; general disinfectant and control of the intermediate snail host of schistosomiasis. The technical grade of sodium pentachlorophenate usually contain toxic microcontaminants including polychlorinated dibenzodioxins and dibenzofurans (132-64-9, and others).
CarcinogenicityData from a wide range and large number of studies evaluating the carcinogenic potential of pentachlorophenol are available. These include three longterm carcinogenicity studies in mice, three in rats, two studies evaluating the potential of pentachlorophenol to act as promoter in the carcinogenic process, and a “stop exposure” study. The results of the initiation and/or promotion studies are uniformly negative, as are the results of all the rat studies and two of the three long-term mouse studies. In addition, a very large body of genotoxicity evidence suggests that pentachlorophenol is nonmutagenic.
Environmental FateRoutes and pathways, relevant physicochemical properties Solubility: in water 330 g l-1 at 25 °C; soluble in ethanol, acetone; insoluble in benzene and petroleum oils. Partition behavior in water, sediment, and soil If released to air, NaPCP will exist solely in the aerosol phase in the ambient atmosphere. The aerosol phase will be removed from the atmosphere by wet and dry deposition. If released to soil and water under typical ambient conditions (pH 5–9), NaPCP is expected to exist predominately in its dissociated form (pKa 4.7). Releases to soil can decrease in concentration due to slow biodegradation (half-life is weeks to months) and leaching into groundwater. Releases to water may photolyze (half-life is hours to days with rate decreasing with depth of water), biodegrade, adsorb to sediments, or bioaccumulate in aquatic organisms. Biodegradation probably becomes significant after a period of acclimation.
Environmental persistency
NaPCP is not persistent in water, sewage, or soil because of bacterial decomposition. PCP readily decomposes in sunlight to monomeric and dimeric oxidation products in water. Principal decompose products are tetrachlororesorcinol, chloranilic acid, and dimeric products.
Bioaccumulation and biomagnification
Sodium pentachlorophenol did not appear to bioaccumulate in aquatic organisms to very high concentrations. BCFs for the compound were <1000 for most species tested.
ShippingUN2567 Sodium pentachlorophenate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Toxicity evaluationThe biochemical action of pentachlorophenol is active uncoupling of oxidation phosphorylation. PCP binds to mitochondrial protein and inhibits mitochondrial ATP-ase activity. Thus, both the formation of ATP and the release of energy to the cell from the breakdown of ATP to ADP are prevented. Electron transport is not inhibited by PCP, although reactions dependent on available high-energy bonds, such as oxidative and glycolytic phosphorylation, are affected. Binding to enzymatic protein has been reported and may lead to the inhibition of other cellular enzymes. There is also an increase in cellular oxygen demand during the uncoupling of oxidative phosphorylation. This causes the initial rise in respiration rate reported in individuals poisoned by PCP.
IncompatibilitiesUses include: wood preservative; as a fungicide in water-based latex paints; preservation of cellulose products, textiles, adhesives, leather, pulp, paper, and industrial waste systems; a contact and preemergence herbicide; general disinfectant and control of the intermediate snail host of schistosomiasis. The technical grade of sodium pentachlorophenate usually contain toxic microcontaminants including polychlorinated dibenzodioxins and dibenzofurans (132-64-9, and others).
Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.
Sodium pentachlorophenolate Preparation Products And Raw materials
Raw materialsPhenol-->HEXACHLOROBENZENE
Preparation ProductsPentachlorophenol-->Chloranil-->PENTACHLOROPHENOL DODECANOATE
2,4,5-TRICHLOROPHENOL SODIUM SALT Sodium benzoate PENTACHLOROPHENOL 13C6 3,5-Dichlorophenol 2,3,4-TRICHLOROPHENOL Pentachlorophenol sodium salt hydrate 2,3,6-TRICHLOROPHENOL 2,4,6-Trichlorophenol Sodium sulfate 2,3,4,5-TETRACHLOROPHENOL,SODIUMSALT 4-CHLOROPHENOL SODIUM SALT Diclofenac sodium Sodium bicarbonate 2,3,5-TRICHLOROPHENOL 2,3-Dichlorophenol 2,3,4,6-TETRACHLOROPHENOL SODIUM SALT Sodium 2,4,6-trichlorophenolate sodium 2-chlorophenolate

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