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| | PATULIN Basic information |
| | PATULIN Chemical Properties |
| Melting point | 108-111 °C | | alpha | D21 -6.2° (chloroform) | | Boiling point | 197.46°C (rough estimate) | | density | 1.1993 (rough estimate) | | refractive index | 1.4300 (estimate) | | Fp | 2℃ | | storage temp. | −20°C | | solubility | ethyl acetate: soluble50mg/mL | | pka | 11.69±0.20(Predicted) | | form | Crystals or Crystalline Powder | | color | White | | Merck | 13,7125 | | BRN | 149675 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. | | CAS DataBase Reference | 149-29-1(CAS DataBase Reference) | | IARC | 3 (Vol. 40, Sup 7) 1987 | | EPA Substance Registry System | Patulin (149-29-1) |
| | PATULIN Usage And Synthesis |
| Description | Spergillus and Penicillium species.
Patulin is also an animal carcinogen, inhibits K1-uptake into
erythrocytes, and inhibits various forms of Na1/K1-ATPase. | | Chemical Properties | white crystals or fine crystalline powder | | Uses | Patulin (PAT), a mycotoxin produced by certain species of Penicillium, Aspergillus, and Byssochlamys, is mainly found in ripe apple and apple products. | | Uses | An inhibitor of protein prenylation | | Definition | ChEBI: A furopyran and lactone that is 2H-pyran-3(6H)-ylidene)acetic acid which is syubstituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give
he corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic. | | Purification Methods | Crystallise patulin from *C6H6, Et2O, EtOH or chloroform. It sublimes at 90o/high vacuum [Bergel et al. J Chem Soc 415 1944]. [Beilstein 18 III/IV 1184, 18/3 V 5.] (Highly TOXIC). | | References | 1) Jin et al. (2016), p53 activation contributes to patulin-induced nephrotoxicity via modulation of reactive oxygen species generation; Sci. Rep., 6 24455
2) Zouaoui et al. (2016), Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells; Food Chem. Toxicol., 89 92
3) Boussabbeh et al. (2016), Tissue oxidative stress induced by patulin and protective effect of crocin; Neurotoxicology, 53 343
4) Pillay et al. (2015), Patulin triggers NRF2-meditated survival mechanisms in kidney cells; Toxicon, 99 1
5) Boussabbeh et al. (2015), Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway; Toxicol. Sci., 144 328 |
| | PATULIN Preparation Products And Raw materials |
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