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Z-TLE-OH DCHA

Z-TLE-OH DCHA Basic information
Product Name:Z-TLE-OH DCHA
Synonyms:3-Methyl-N-[(phenylmethoxy)carbonyl]-L-valine compd. with N-cyclohexylcyclohexanamine;Z-L-tert-butyl-Gly-OH·DCHA;Z-L-Tle-OH·DCHA;(-)-N-Benzyloxycarbonyl-L-tert-leucine dicyclohexyl ammonium salt for synthesis;N-ALPHA-CARBOBENZOXY-L-ALPHA-T-BUTYLGLYCINE DICYCLOHEXYLAMINE SALT;N-ALPHA-CARBOBENZOXY-L-TERT-LEUCINE DICYCLOHEXYLAMINE SALT;(-)-N-BENZYLOXYCARBONYL-L-TERT-LEUCINE DICYCLOHEXYLAMMONIUM SALT;Z-ALPHA-T-BUTYL-GLY-OH DCHA
CAS:62965-37-1
MF:C14H19NO4.C12H23N
MW:446.63
EINECS:478-250-9
Product Categories:
Mol File:62965-37-1.mol
Z-TLE-OH DCHA Structure
Z-TLE-OH DCHA Chemical Properties
Melting point 163-167 °C
density 1.1 at 20℃
vapor pressure 0Pa at 25℃
storage temp. 2-8°C
form Solid
PH6.3 (H2O, 20℃)(saturated solution)
optical activity[α]20/D 6.5±1°, c = 1% in methanol
BRN 3831936
LogP1.6 at 25℃ and pH2.5
Surface tension63mN/m at 1g/L and 20℃
Safety Information
Safety Statements 22-24/25
WGK Germany 3
F 10-21
HS Code 2906190090
MSDS Information
ProviderLanguage
SigmaAldrich English
Z-TLE-OH DCHA Usage And Synthesis
Uses3-methyl-N-[(phenylmethoxy)carbonyl]-L-Valine, with N-cyclohexylcyclohexanamine is used in the preparation of an intermediate towards the interleukin-1β converting enzyme inhibitor VX-765 using the palladium-catalyzed coupling of a bromodihydrofuranone with Cbz-L-prolinamide as the key step.
Z-TLE-OH DCHA Preparation Products And Raw materials
Preparation ProductsCbz-L-tert-Leucine
Z-ASP-OME Z-TYR-OH Z-VAL-OSU Z-VAL-NH2 Z-VAL-PHE-OME Z-TYR(TBU)-OSU Z-TYR-ONP N-CARBOBENZOXY-DL-LEUCINE Z-TYR-OME CBZ-L-VALINOL Cbz-L-tert-Leucine (-)-N-FORMYL-L-TERT-LEUCINE N-CARBOBENZOXY-DL-VALINE Z-TLE-OH DCHA N-Carbobenzyloxy-L-valine Methoxycarbonyl-L-tert-leucine DL-tert-Leucine L-tert-Leucine
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