ChemicalBook Product Catalog Chemical Reagents Organic reagents Sulfonates / Sulfinates Hydroxylamine-O-sulfonic acid

Hydroxylamine-O-sulfonic acid

Hydroxylamine-O-sulfonic acid Basic information
Product Name:Hydroxylamine-O-sulfonic acid
Synonyms:amidoperoxymonosulfuricacid;amidosulfonicperacid;aminomonopersulfuricacid;haos;o-hydroxylammoniumsulfonate;permonosulfamicacid;sulfoperamidicacid;HOS
CAS:2950-43-8
MF:H3NO4S
MW:113.09
EINECS:220-971-6
Product Categories:Building Blocks;Chemical Synthesis;Pharmaceutical Intermediates;Organic Building Blocks;Sulfonic/Sulfinic Acids;Sulfur Compounds;Amination;Hydroxylamines;Hydroxylamines (O-Substituted);Synthetic Organic Chemistry;Organic Building Blocks;Sulfonic/Sulfinic Acids;Sulfur Compounds;bc0001
Mol File:2950-43-8.mol
Hydroxylamine-O-sulfonic acid Structure
Hydroxylamine-O-sulfonic acid Chemical Properties
Melting point 210 °C (dec.)(lit.)
Boiling point 39 °C(Press: 0.4 Torr)
density 2.2 g/cm3 (20℃)
vapor pressure 0-53.329Pa at 25-39℃
storage temp. 2-8°C
solubility 675g/l (slow decomposition)
pka-6.47±0.18(Predicted)
form Crystalline Powder
color White
PH0.8 (100g/l, H2O, 20℃)
Water Solubility soluble
Sensitive Hygroscopic
BRN 956566
InChIKeyDQPBABKTKYNPMH-UHFFFAOYSA-N
CAS DataBase Reference2950-43-8(CAS DataBase Reference)
EPA Substance Registry SystemHydroxylamine-O-sulfonic acid (2950-43-8)
Safety Information
Hazard Codes C,N
Risk Statements 34-50-43-40-22
Safety Statements 26-36/37/39-45-61-28A-27-22
RIDADR UN 3260 8/PG 3
WGK Germany 3
RTECS NC5427000
F 10-21
Hazard Note Irritant
TSCA Y
HazardClass 8
PackingGroup III
HS Code 28111980
MSDS Information
ProviderLanguage
HOSA English
ACROS English
SigmaAldrich English
ALFA English
Hydroxylamine-O-sulfonic acid Usage And Synthesis
Chemical Propertieswhite to slightly beige crystalline powder
UsesHydroxylamine-O-sulfonic acid is used in the synthesis of quinolones for the benzodiazepine site of GABAA receptors. It is also used as a polymerization catalyst and an amination reagent. It is involved in the preparation of diazene by reacting with an alkali. It is also used in the inhibition of polychlorinated dibenzo-p-dioxins (PCDD) as well as (polychlorinated biphenyl) PCB formation in co-combustion.
UsesHydroxylamine-O-sulfonic acid (HOSA) may be used to synthesize (Z)-1H-purin-6(7H)-ylideneaminooxysulfonic acid.
HOSA may be used as an aminating reagent in the synthesis of:
  • 1-aminotetrazoles and 2-aminotetrazoles
  • N-aminopiperidine (NAPP)
  • 1H,1′ H-2,2′-biimidazole-1,1′-diamine
General DescriptionHydroxylamine-O-sulfonic acid is a versatile synthetic reagent. It is widely employed as a nucleophile and as an electrophile in various organic syntheses. It can be synthesized by reacting hydroxylamine sulfate with 30% fuming H2SO4.
Purification MethodsStir the solid vigorously with anhydrous Et2O and filter it off using large volumes of dry Et2O. Drain dry at the pump for 5minutes and then for 12-14hours in a vacuum. Store it in a vacuum desiccator over conc H2SO4. Determine the purity by oxidation of iodide to I2. It must be stored in a dry atmosphere at 0-4o. It decomposes slowly in H2O at 25o and more rapidly above this temperature. [Matsuguma & Andrieth Inorg Synth V 122 1957.]
Hydroxylamine-O-sulfonic acid Preparation Products And Raw materials
Preparation Products1-ISOPROPYL-5-HYDROXYPYRAZOL-->Dimethylglyoxime-->Pyrazolo[1,5-a]pyridine-3-carboxylic acid-->1H-INDOL-1-AMINE-->3-(3-Nitrophenyl)propionic acid
2,7-Naphthalenedisulfonic acid disodium salt N,N-Diethylhydroxylamine Aniline-2-sulfonic acid 2-Diazo-1-naphthol-5-sulfonic acid Ethyl 2-(Chlorosulfonyl)acetate HYDROXYLAMINE NITRATE HYDROXYLAMINE sodium benzaldehyde-o-sulfonate 4-NITRO-2-SULFOANILINE SULFONIC ACID Folic acid Glycine Hydroxylamine-O-sulfonic acid N-Phenylhydroxylamine METARAMINOL Hydroxylamine hydrochloride Hydroxylamine sulfate phosphoric acid
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