ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Benzylpyridinium 4-Benzylpyridine

4-Benzylpyridine

4-Benzylpyridine Basic information
Product Name:4-Benzylpyridine
Synonyms:PHENYL-4-PYRIDYLMETHANE;4-(phenylmethyl)-pyridin;4-BENZYLPYRIDINE FOR SYNTHESIS;CHEMICALS OTHER THAN DRUGS & COSMETICS:4-BENZYLPYRIDINE;4-Benzylpyridine ,98%;4-Benzylpyridine, 97% 100ML;4-Benzylpyridine, 97% 5ML;g-Benzylpyridine
CAS:2116-65-6
MF:C12H11N
MW:169.22
EINECS:218-319-0
Product Categories:C9 to C46;Heterocyclic Building Blocks;Pyridines, Pyrimidines, Purines and Pteredines;Pyridines
Mol File:2116-65-6.mol
4-Benzylpyridine Structure
4-Benzylpyridine Chemical Properties
Melting point 9-11 °C
Boiling point 287 °C (lit.)
density 1.061 g/mL at 25 °C (lit.)
refractive index n20/D 1.582(lit.)
Fp 239 °F
storage temp. Indoors
solubility Chloroform (Slightly), Methanol (Slightly)
form Liquid
pka5.75±0.10(Predicted)
color yellow
PH8 (H2O, 20℃)
Water Solubility Soluble in ethanol, ethyl ether. Insoluble in water.
BRN 115831
LogP2.620
CAS DataBase Reference2116-65-6(CAS DataBase Reference)
NIST Chemistry ReferencePyridine, 4-(phenylmethyl)-(2116-65-6)
EPA Substance Registry SystemPyridine, 4-(phenylmethyl)- (2116-65-6)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS US2625000
TSCA Yes
HS Code 29333999
ToxicityLD50 ivn-mus: 25 mg/kg CSLNX* NX#12240orl-bwd LD50:18 mg/kg TXAPA9 21,315,72
MSDS Information
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4-Benzylpyridine English
ACROS English
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4-Benzylpyridine Usage And Synthesis
Chemical Propertiescolorless or clear slightly yellow liquid. Boiling point 284-287°C, 180-181°C (4.13kPa). Relative density 1.062, refractive index 1.5785. soluble in ethanol, ether, insoluble in water.
Uses4-Benzylpyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, dyes and agrochemicals.It is the key raw material for the synthesis of Ifenprodil hemitartrate.
Preparation4-Benzylpyridine is synthesized from benzyl chloride and pyridine.
Synthesis Reference(s)The Journal of Organic Chemistry, 27, p. 1889, 1962 DOI: 10.1021/jo01052a509
Safety ProfilePoison by ingestion andintravenous routes. A flammable material. Incompatible with oxidizers. When heated to decomposition it emitstoxic fumes of NOx.
Purification MethodsDry it with NaOH for several days, then distil it from CaO under reduced pressure, and redistil the middle fraction. [Beilstein 20/7 V 561.]
4-Benzylpyridine Preparation Products And Raw materials
Raw materialsBenzyl chloride
Preparation Products4-(4-Nitrobenzyl)pyridine-->4-benzyl-1-methyl-piperidine
2-BENZYLPYRIDINE,2-Benzylpyridine, 98+% 4-(4-PYRIDYLMETHYL)ANILINE Benzyl chloride Benzyltriethylammonium chloride 2-Chloro-5-chloromethylpyridine 4-Phenylpyridine Phenylacetone 4-Methylpyridine (-)-2-[METHYLAMINO]-1-PHENYLPROPANE 4-(4-CHLOROBENZYL)PYRIDINE 4-Benzylpyridine BENZ[G]ISOQUINOLINE-5,10-DIONE 2,6-Lutidine 2,4,6-Collidine 4-(4-CHLOROBENZOYL)PYRIDINE N,N-Dimethylbenzylamine 4-(4-NITROBENZYL)-1-[2-(SULFONATOOXY)ETHYL]PYRIDINIUM BENZYL GLYCIDYL ETHER
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