N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Basic information

Product Name:	N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
Synonyms:	N-(2-Amino-4.6-dichloro-5-pyrimdinyl) formamide;2-Amino-4,6-dichloro-5-pyrimidinyl formamide;2,5-Diamino-4,6-DichloroformamidoHcl;N-(2-Amino-4,6-Dichloro-5-Pyri;N-(2-AMINO-4,6-DICHLOROPYRIMIDIN-5-YL) FORMAMIDE[FOR ABACAVIR];N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide;N-(2-Amino-4,6-dichloropyrimidin-5-yl)formamide;2-Amino-4,6-dichloro-5-formamidopyrimidine
CAS:	171887-03-9
MF:	C5H4Cl2N4O
MW:	207.02
EINECS:	425-650-6
Product Categories:	Heterocycle-Pyrimidine series;Bases & Related Reagents;Heterocycle;Heterocyclic Compounds;Heterocycles;Nucleotides;3
Mol File:	171887-03-9.mol

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Chemical Properties

Melting point	>251°C (dec.)
Boiling point	554.8±60.0 °C(Predicted)
density	1.742±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	DMSO, Methanol
form	Solid
pka	10.90±0.70(Predicted)
color	Off-White to Pale Beige
CAS DataBase Reference	171887-03-9(CAS DataBase Reference)

Safety Information

HS Code

2933.59.9500

MSDS Information

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Usage And Synthesis

Chemical Properties	White crystalline powder
Uses	N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Uses	Abacavir intermediate. A purine derivative
Uses	Prasugrel intermediate

N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide Preparation Products And Raw materials

Raw materials

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