ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyrimidines Methylpyrimidine 4-Hydroxy-6-(trifluoromethyl)pyrimidine

4-Hydroxy-6-(trifluoromethyl)pyrimidine

4-Hydroxy-6-(trifluoromethyl)pyrimidine Basic information
Product Name:4-Hydroxy-6-(trifluoromethyl)pyrimidine
Synonyms:6-TRIFLUOROMETHYL-4-PYRIMIDINOL;6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL;4-HYDROXY-6-TRIFLUOROMETHYLPYRIMIDINE;4-PYRIMIDINOL, 6-(TRIFLUOROMETHYL)-;4-Hydroxy-6-(trifluormethyl)-pyrimidin;6-TRIFLUOROMETHYL-4-PYRIMIDINOL 98+%;6-Trifluoromethyl-4(1H)-pyrimidinone;4-Hydroxy-6-(trifluoromethyl)pyrimidine ,98%
CAS:1546-78-7
MF:C5H3F3N2O
MW:164.09
EINECS:
Product Categories:Boronic Acid;Heterocyclic Compounds;Pyrimidine series;Fluorinated pyrimidine derivatives;Pyrimidines;alcohol;Fluorine series
Mol File:1546-78-7.mol
4-Hydroxy-6-(trifluoromethyl)pyrimidine Structure
4-Hydroxy-6-(trifluoromethyl)pyrimidine Chemical Properties
Melting point 169-171 °C(lit.)
Boiling point 130.3±50.0 °C(Predicted)
density 1.55±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka6.41±0.40(Predicted)
form Crystalline
color White
Water Solubility Solubility in methanol (almost transparency). Slightly soluble in water.
BRN 145548
CAS DataBase Reference1546-78-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HazardClass IRRITANT
HS Code 29335990
MSDS Information
ProviderLanguage
SigmaAldrich English
4-Hydroxy-6-(trifluoromethyl)pyrimidine Usage And Synthesis
Chemical PropertiesWhite powder
Uses4-Hydroxy-6-(trifluoromethyl)pyrimidine is used as building block in chemical synthesis. Attributes Development Product Contact
Uses4-Hydroxy-6-(trifluoromethyl)pyrimidine (6-(Trifluoromethyl)-4-pyrimidinol) may be used in the synthesis of 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin.
Synthesis Reference(s)Journal of the American Chemical Society, 80, p. 5744, 1958 DOI: 10.1021/ja01554a041
General Description4-Hydroxy-6-(trifluoromethyl)pyrimidine, a pyrimidine derivative, is a heterocyclic building block.
4-Hydroxy-6-(trifluoromethyl)pyrimidine Preparation Products And Raw materials
Raw materialsEthanol-->Hydrochloric acid-->Ethyl acetate-->Methanol-->Sodium-->Sodium sulfate-->Hexane-->Ethyl 4,4,4-trifluoroacetoacetate-->Formamidine acetate-->FORMAMIDINE HYDROCHLORIDE
Preparation Products4-Chloro-6-trifluoromethylpyrimidine
2-(3-PYRIDINYL)-6-(TRIFLUOROMETHYL)-4-PYRIMIDINOL 2-(DIMETHYLAMINO)-6-(TRIFLUOROMETHYL)-4-PYRIMIDINOL Benzotrifluoride (Trifluoromethyl)trimethylsilane METHYL 2-([2-(2-PYRIDINYL)-6-(TRIFLUOROMETHYL)-4-PYRIMIDINYL]OXY)BENZENECARBOXYLATE 4-Aminobenzotrifluoride 4-PHENOXY-2-(2-PYRIDINYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE 4,6-Dihydroxypyrimidine 4-Hydroxypyrimidine 4-Hydroxy-6-(trifluoromethyl)pyrimidine Trifluoromethyl 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Trifluridine Pirimiphos-methyl 4-Ethyl-5-fluoro-6-hydroxypyrimidine Lithium triflate CHLOROPHOSPHONAZO III 2-AMINO-4-HYDROXY-6-(TRIFLUOROMETHYL)PYRIMIDINE
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