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5-Chloropyrimidin-2-amine

5-Chloropyrimidin-2-amine Basic information
Product Name:5-Chloropyrimidin-2-amine
Synonyms:TIMTEC-BB SBB005486;5-CHLORO-2-PYRIMIDINAMINE;2-AMINO-5-CHLOROPYRIMIDINE;5-chloropyrimidin-2-amine;2-Pyrimidinamine, 5-chloro- (9CI);5-chlorpyrimidin-2-amin;5-chloro-2-pyrimidinylamine;5-chloro-pyrimidin-2-ylamine
CAS:5428-89-7
MF:C4H4ClN3
MW:129.55
EINECS:226-581-2
Product Categories:Heterocycle-Pyrimidine series;Heterocyclic Building Blocks;PYRIMIDINE;Pyridines, Pyrimidines, Purines and Pteredines;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Building Blocks;Halogenated Heterocycles
Mol File:5428-89-7.mol
5-Chloropyrimidin-2-amine Structure
5-Chloropyrimidin-2-amine Chemical Properties
Melting point 235-238 °C (lit.)
Boiling point 314.6±34.0 °C(Predicted)
density 1.437±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form powder to crystal
pka1.93±0.10(Predicted)
color White to Almost white
BRN 110914
InChIKeyOQZMDDKDHRIGDY-UHFFFAOYSA-N
CAS DataBase Reference5428-89-7(CAS DataBase Reference)
NIST Chemistry Reference2-Amino-5-chloropyrimidine(5428-89-7)
EPA Substance Registry System2-Pyrimidinamine, 5-chloro- (5428-89-7)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-41
Safety Statements 26-36/37
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS UV6329500
Hazard Note Irritant
TSCA Yes
HazardClass 6.1
PackingGroup Ⅲ
HS Code 29335990
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
5-Chloropyrimidin-2-amine Usage And Synthesis
Uses5-Chloropyrimidin-2-amine is an useful reagent of research interest in the preparation of JAK2 inhibitors for the treatment of myeloproliferative disorders and SIRT2 inhibitors for the treatment of Huntington''s disease.
Synthesis Reference(s)Journal of the American Chemical Society, 64, p. 567, 1942 DOI: 10.1021/ja01255a030
5-Chloropyrimidin-2-amine Preparation Products And Raw materials
Raw materials2-CHLOROMALONALDEHYDE-->Mucochloric acid-->Guanidine nitrate-->Guanidine carbonate
Preparation Products2-Aminopyrimidine-->N-(5-Chloropyrimidin-2-yl)acetamide
Acetaminophen 5-CHLORO-4-[(2-CHLOROBENZYL)SULFANYL]-6-METHYL-2-PYRIMIDINAMINE EC 2.6.1.2 METHYL 2-[(2-AMINO-5-CHLORO-6-METHYL-4-PYRIMIDINYL)SULFANYL]ACETATE ALTRENOGEST Triallylamine Dibenzylamine 6-Aminocaproic acid Glycine 2-Aminopyrimidine 5-Chloropyrimidin-2-amine 2-AMINO-5-CHLOROPYRIMIDINE-4-CARBOXYLIC ACID Bis(2-ethylhexyl)amine 2-[(2-AMINO-5-CHLORO-6-METHYL-4-PYRIMIDINYL)SULFANYL]-N-METHYLACETAMIDE Tris(hydroxymethyl)aminomethane AMINO ACIDS 3-Aminophenol N-(5-CHLORO-2-PYRIMIDINYL)-4-METHYLBENZENECARBOXAMIDE
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