5-Chlorosalicylaldehyde

5-Chlorosalicylaldehyde Basic information

Product Name:	5-Chlorosalicylaldehyde
Synonyms:	5-CHLOROSALICYLALDEHYDE;5-Chlorosalicylic aldehyde;5-CHLORO-2-HYDROXYBENZALDEHYDE;2-HYDROXY-5-CHLOROBENZALDEHYDE;AKOS 90774;5-Chlorosalicyladehyde;5-Cl-salicylal;5-Chloro-2-Hydroxybenzaldehyde (5-Chlorosalicylaldehyde)
CAS:	635-93-8
MF:	C7H5ClO2
MW:	156.57
EINECS:	211-244-4
Product Categories:	Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Adehydes, Acetals & Ketones;Chlorine Compounds;Phenols;Aldehydes;FINE Chemical & INTERMEDIATES;Alcohols and Derivatives;Carbonyl Compounds;C7;Carbonyl Compounds;bc0001
Mol File:	635-93-8.mol

5-Chlorosalicylaldehyde Chemical Properties

Melting point	100-102 °C(lit.)
Boiling point	217.69°C (rough estimate)
density	1.2683 (rough estimate)
refractive index	1.5812 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	7.73±0.18(Predicted)
form	Crystalline Powder
color	White to very slightly yellow
Sensitive	Air Sensitive
BRN	636632
LogP	2.570 (est)
CAS DataBase Reference	635-93-8(CAS DataBase Reference)
NIST Chemistry Reference	5-Chloro-2-hydroxy benzaldehyde(635-93-8)
EPA Substance Registry System	Benzaldehyde, 5-chloro-2-hydroxy- (635-93-8)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/21/22
Safety Statements	26-36-24/25-36/37/39
RIDADR	UN2811/6.1/PG III
WGK Germany	3
RTECS	VN5450000
Hazard Note	Irritant
TSCA	Yes
HS Code	29130000

MSDS Information

Provider	Language
5-Chlorosalicylic aldehyde	English
SigmaAldrich	English
ACROS	English
ALFA	English

5-Chlorosalicylaldehyde Usage And Synthesis

Chemical Properties	white to very slightly yellow crystalline powder
Uses	5-Chlorosalicyaldehyde is a useful synthetic intermediate and a key precursor to a variety chelating agents.5-Chlorosalicyaldehyde is used to synthesize imine resveratrol (R150000) derivatives as multi-targeted agents against Alzheimer's disease.
Synthesis Reference(s)	Synthetic Communications, 20, p. 609, 1990 DOI: 10.1080/00397919008244911 Tetrahedron Letters, 15, p. 3463, 1974
Purification Methods	Steam distil it, then crystallise it from aqueous EtOH or *C6H6 (m 100o). It forms complexes with Cu2+ and Fe2+ . [Beilstein 8 H 53, 8 II 45, 8 III 181, 8 IV 224.]

5-Chlorosalicylaldehyde Preparation Products And Raw materials

Raw materials

Salicylaldehyde

Preparation Products

5-CHLOROBENZOFURAN-2-CARBOXYLIC ACID-->5-CHLORO-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER-->6-CHLORO-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID-->Diethyl succinosuccinate-->5-CHLORO-2-HYDROXYBENZYL ALCOHOL-->5-CHLORO-2-HYDROXY-3-NITRO-BENZALDEHYDE-->6-CHLORO-2H-1-BENZOPYRAN-3-CARBOXYLIC ACID-->3-Bromo-5-chlorosalicylaldehyde-->Ethyl 6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate-->1,2,3-benzoxathiazine, 6-chloro-, 2,2-dioxide-->2-(BENZYLOXY)-5-CHLOROBENZALDEHYDE-->2H-1-Benzopyran-2-one, 6-chloro-4-hydroxy-3-Methyl-

1-Chloro-2-methylpropane 3-Chloropivaloyl chloride 6-CHLOROCHROMAN-4-ONE 1-Nonanal Paraldehyde Chlorocyclohexane Difluorochloromethane 5-Chlorosalicylaldehyde 3-BROMO-5-CHLOROSALICYLALDEHYDE Salicylaldehyde METHYL 5-CHLORO-2-METHOXYBENZOATE 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID N-Chlorosuccinimide 5-Chloro-2-hydroxybenzoic acid 2-Ethoxy-4-amino-5-chlorobenzoic acid Methyl 5-chloro-2-hydroxybenzoate 6,8-DICHLORO-3-FORMYLCHROMONE 5-Chloro-2-methoxybenzoic acid

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