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| | VISNAGIN Basic information |
| Product Name: | VISNAGIN | | Synonyms: | 5-METHOXY-2-METHYL-FURANOCHROMONE;4-METHOXY-7-METHYL-5H-FURO[3,2-G][1]-BENZOPYRAN-5-ONE;4-METHOXY-7-METHYL-FURO[3,2-G]CHROMEN-5-ONE;LABOTEST-BB LT00441024;VISNAGIN;2-g)(1)benzopyran-5-one,4-methoxy-7-methyl-5h-furo(;desmethoxykhellin;visnagidin | | CAS: | 82-57-5 | | MF: | C13H10O4 | | MW: | 230.22 | | EINECS: | 201-430-3 | | Product Categories: | Chromones | | Mol File: | 82-57-5.mol |  |
| | VISNAGIN Chemical Properties |
| Melting point | 139-142 °C | | Boiling point | 292.2°C (rough estimate) | | density | 1.1302 (rough estimate) | | refractive index | 1.4300 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). | | form | Fine Crystalline Powder | | color | Beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | LogP | 2.260 (est) | | CAS DataBase Reference | 82-57-5(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | RTECS | LV1420000 | | HS Code | 29162000 |
| Provider | Language |
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ACROS
| English |
| | VISNAGIN Usage And Synthesis |
| Description | Visnagin (82-57-5) is a natural product isolated from the plant Ammi visnaga.? It displays protective effects against doxorubicin-induced cardiomyopathy via inhibition of mitochondrial malate dehydrogenase resulting in a decrease in cardiomyocyte apoptosis.1 | | Chemical Properties | BEIGE FINE CRYSTALLINE POWDER | | Uses | antiinflammatory, neuroprotective | | Definition | ChEBI: Visnagin is a furanochromone that is furo[3,2-g]chromen-5-one which is substituted at positions 4 and 7 by methoxy and methyl groups, respectively. Found in the toothpick-plant, Ammi visnaga. It has a role as a phytotoxin, an EC 1.1.1.37 (malate dehydrogenase) inhibitor, a vasodilator agent, an antihypertensive agent, an anti-inflammatory agent and a plant metabolite. It is a furanochromone, an aromatic ether and a polyketide. It is functionally related to a 5H-furo[3,2-g]chromen-5-one. | | Purification Methods | Crystallise visnagin from water. It is soluble in CHCl3 but slightly soluble in EtOH. [Aneja et al. Tetrahedron 3 230 1958, Beilstein 19 III/IV 2640.] | | References | 1) Liu et al. (2014), Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase; Sci. Transl. Med. 6 266ra170 |
| | VISNAGIN Preparation Products And Raw materials |
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