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| | 4-Methylimidazole Basic information |
| | 4-Methylimidazole Chemical Properties |
| Melting point | 44-47 °C(lit.) | | Boiling point | 263 °C(lit.) | | density | 1.02 | | refractive index | 1.5037 | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | H2O: soluble, clear, colorless to yellow (50 mg/mL) | | form | Powder | | pka | pK1:7.55(＋1) (25°C) | | color | Reddish-brown to green to brown | | Water Solubility | Soluble in water. | | BRN | 1453 | | InChIKey | XLSZMDLNRCVEIJ-UHFFFAOYSA-N | | LogP | 0.230 | | CAS DataBase Reference | 822-36-6(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Methylimidazole(822-36-6) | | IARC | 2B (Vol. 101) 2013 | | EPA Substance Registry System | 1H-Imidazole, 4-methyl- (822-36-6) |
| | 4-Methylimidazole Usage And Synthesis |
| Chemical Properties | Slightly yellow chunks. soluble in water and ethanol. | | Uses | 4-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results f
rom the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen. | | Uses | 4-Methylimidazole is used for the curing agent of epoxy resin, the main raw material of medicine cimetidine. It can also be used for synthesis of antibacterial agent. | | Preparation | 4-Methylimidazole is synthesized by the reaction of glyoxal, acetaldehyde and ammonia. Another method to synthesize the compound is by catalytic dehydrogenation of imidazoline derivatives. 4-Methylimidazole may be synthesized from propanol and formamide, by catalytic cyclization of bisformamidipropane or by photolysis of alkenyltetrazole derived from alkenes by sequential epoxidation, ring opening and dehydration (NTP, 2007). | | Definition | ChEBI: 4-methylimidazole is imidazole substituted at position 4 by a methyl group. It has a role as a carcinogenic agent and a reaction intermediate. | | General Description | 4(5)-Methylimidazole was quantified in coffee by GC-MS method. | | Purification Methods | Recrystallise 4-methylimidazole from *benzene or pet ether. It has m 56o after sublimation. The picrate has m 162-163.5o (from EtOH). [Beilstein 23 II 60, 23 III/IV 597, 23/5 V 89.] |
| | 4-Methylimidazole Preparation Products And Raw materials |
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