Thiazole-5-carboxaldehyde

Thiazole-5-carboxaldehyde Basic information
Product Name:Thiazole-5-carboxaldehyde
Synonyms:5-THIAZOLECARBOXALDEHYDE;THIAZOLE-5-CARBALDEHYDE;THIAZOLE-5-CARBOXALDEHYDE;1,3-Thiazole-5-carboxaldehyde;Thiazole-5-carboxyaldehyde;5-THIAOLECARBOXALDEHYDE;5-Formylthiazole;Thiazole-5-carboxaldehyde ,97%
CAS:1003-32-3
MF:C4H3NOS
MW:113.14
EINECS:
Product Categories:Building Blocks;Thiazole;Aldehydes;blocks;Building Blocks;Heterocyclic Building Blocks;Thiazoles
Mol File:1003-32-3.mol
Thiazole-5-carboxaldehyde Structure
Thiazole-5-carboxaldehyde Chemical Properties
Melting point 229 °C (decomp)
Boiling point 92-94 °C/16 mmHg
density 1.304 g/mL at 25 °C
refractive index 1.5874
Fp 98 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka0.94±0.10(Predicted)
form powder to lump to clear liquid
color White or Colorless to Yellow
InChIKeyZXRLWHGLEJGMNO-UHFFFAOYSA-N
CAS DataBase Reference1003-32-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-43-36-22
Safety Statements 26-36/37/39-36/37
WGK Germany 3
HazardClass IRRITANT
HS Code 29341000
MSDS Information
Thiazole-5-carboxaldehyde Usage And Synthesis
Chemical PropertiesWhite to brown liquid or solid
UsesThiazole-5-carboxaldehyde is used in the synthesis of imidazoles with cardiomyocyte proliferation activity for heart disease treatments.
Synthesis Reference(s)Synthetic Communications, 25, p. 4081, 1995 DOI: 10.1080/00397919508011485
Synthesis, p. 998, 1987 DOI: 10.1055/s-1987-28146
Purification MethodsDry the aldehyde over Na2SO4 and fractionate it in a vacuum. The 2,4-dinitrophenylhydrazone forms red crystals from MeOH with m 238-240o, and the semicarbazone has m 210-212o (from MeOH). [Erne et al. Helv Chim Acta 34 148 1951, Beilstein 27 III/IV 2615.]
Thiazole-4-carboxaldehyde Benzothiazole N-(3-ACETYL-4-METHYL(2,5-THIAZOLYL))-2,2,2-TRIFLUOROETHANAMIDE 4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBOHYDRAZIDE THIAZOLE ORANGE 2-Mercaptobenzothiazole Fosthiazate Ethyl 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate 2-Amino-4-methyl-5-acetylthiazole ETHYL 2,4-DIMETHYLTHIAZOLE-5-CARBOXYLATE Ethyl 2-amino-4-phenyl-5-thiazolecarboxylate 1,3-Thiazole-2-carbaldehyde Formaldehyde Thiazole-5-carboxaldehyde Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) (4-CHLOROPHENYL)(2-PHENYL-1,3-THIAZOL-5-YL)METHANONE Thiazole 2-(2-Aminothiazol-4-yl)glyoxylic acid

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