ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Methylpyridine 3-(Trifluoromethyl)pyridine-2-carboxylic acid

3-(Trifluoromethyl)pyridine-2-carboxylic acid

3-(Trifluoromethyl)pyridine-2-carboxylic acid Basic information
Product Name:3-(Trifluoromethyl)pyridine-2-carboxylic acid
Synonyms:3-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXYLIC ACID;3-(TRIFLUOROMETHYL)PICOLINIC ACID;3-(TRIFLUOROMETHYL)-2-PICOLINIC ACID;3-(trifluoromethyl)-2-pyridinecarboxylic acid;3-(Trifluoromethy)pyridine-2-carboxylic acid;3-(Trifluoromethyl)-2-pyridinecarboxylicacid(en);3-(Trifluoromethyl)picolinic acid, 2-Carboxy-3-(trifluoromethyl)pyridine;2-Pyridinecarboxylic acid, 3-(trifluoromethyl)-
CAS:87407-12-3
MF:C7H4F3NO2
MW:191.11
EINECS:
Product Categories:Carboxylic Acids;Pyridines;Acids and Derivatives;Heterocycles;Carboxylic Acids;Fluorine series;Aromatics;Intermediates
Mol File:87407-12-3.mol
3-(Trifluoromethyl)pyridine-2-carboxylic acid Structure
3-(Trifluoromethyl)pyridine-2-carboxylic acid Chemical Properties
Melting point 125-130°C
Boiling point 274.4±40.0 °C(Predicted)
density 1.484±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka2.67±0.36(Predicted)
color Off-White
Safety Information
Hazard Codes Xi,T
Risk Statements 25-36/37/38
Safety Statements 26-45
RIDADR 2811
WGK Germany 3
HazardClass IRRITANT
PackingGroup Ⅲ
HS Code 2933399990
MSDS Information
3-(Trifluoromethyl)pyridine-2-carboxylic acid Usage And Synthesis
UsesAs Picolinic acid (P437220) derivative, 3-(Trifluoromethyl)pyridine-2-carboxylic acid can be used in the synthesis of oxazine derivatives that act as BACE inhibitors for treatment of diabetes and neurological disorders.
UsesPicolinic acid (P437220) derivative used in the synthesis of oxazine derivatives that act as BACE inhibitors for treatment of diabetes and neurological disorders.
Synthesis Reference(s)Tetrahedron, 50, p. 12259, 1994 DOI: 10.1016/S0040-4020(01)89575-2
3-(Trifluoromethyl)pyridine-2-carboxylic acid Preparation Products And Raw materials
Raw materials2-Bromo-3-trifluoromethylpyridine-->2-Chloro-3-(trifluoromethyl)pyridine-->3-Trifluoromethylpyridine-->CARBON DIOXIDE
3-Trifluoromethylpyridine (Trifluoromethyl)trimethylsilane Methyl propyl carbonate 3-(Trifluoromethyl)benzaldehyde 3-（trifluoromethyl) Cinnamaldehyde 2-Chloro-3-(trifluoromethyl)pyridine PHRIDINE ACETATE 6-Chloro-3-(trifluoromethyl)pyridine-2-carboxylic acid Ethyl 3-(trifluoromethyl)picolinate 3-(Trifluoromethyl)pyridine-2-carboxylic acid Trifluoromethyl 2,5-PYRIDINEDICARBOXYLIC ACID Chromium picolinate 2,6-Lutidine 2,4,6-Collidine CARBOXYLIC ACID 2-(Trifluoromethyl)pyridine Pyridine
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