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Trimebutine maleate

Trimebutine maleate Basic information
Product Name:Trimebutine maleate
Synonyms:3,4,5-trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester maleate;3,4,5-TRIMETHOXYBENZOIC ACID 2-(DIMETHYLAMINO)-2-PHENYLBUTYL ESTER MALEATE SALT;2'-PHENYL-2'-DIMETHYLAMINO-N-BUTYL 3,4,5-TRIMETHOXYBENZOATE MALEATE;2-(dimethylamino)-2-phenylbutyl 3,4,5-trimethoxybenzoate maleate;Cerekinon;Digerent;Modulon;Polibutin
CAS:34140-59-5
MF:C26H33NO9
MW:503.54
EINECS:251-845-9
Product Categories:Active Pharmaceutical Ingredients;API's;Pharmaceuticals;Intermediates & Fine Chemicals;Amines
Mol File:34140-59-5.mol
Trimebutine maleate Structure
Trimebutine maleate Chemical Properties
Melting point 122-124°C
storage temp. 2-8°C
solubility Slightly soluble in water, soluble in acetonitrile, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent).
form neat
color White
InChIKeyFSRLGULMGJGKGI-BTJKTKAUSA-N
CAS DataBase Reference34140-59-5(CAS DataBase Reference)
Safety Information
Hazard Codes C
Risk Statements 34
Safety Statements 26-27-36/37/39-45
WGK Germany 2
RTECS DI0360000
MSDS Information
ProviderLanguage
SigmaAldrich English
Trimebutine maleate Usage And Synthesis
Chemical PropertiesWhite Solid
UsesTrimebutine maleate is an antispasmodic that functions as an opioid receptor agonist. Its mechanism of action involves regulating bowel movements and enhancing gastrointestinal function. Trimebutine is commonly used in the treatment of Irritable bowel syndrome. It is also used to restart the movement of the gut after abdominal surgery and to prevent intestinal blockage (paralytic ileus).
DefinitionChEBI: Trimebutine maleate is a trihydroxybenzoic acid that is proposed as a spasmolytic with possible local anesthetic action for the treatment of gastrointestinal disorders.
Side effectsPossible side effects of trimebutine may include dry mouth, heartburn, nausea, diarrhea, constipation, drowsiness, dizziness, tiredness, indigestion, or headache. Other less frequent side effects are difficulty urinating, hearing loss, or painful breast enlargement. If any of these symptoms persist or worsen, please inform your doctor or pharmacist immediately.
Referenceshttps://www.drugs.com/medical-answers/trimebutine-3571789/
Trimebutine: abuse, addiction and overdose
https://myhealth.alberta.ca/Health/medications/Pages/conditions.aspx?hwid=fdb8090
Trimebutine maleate Preparation Products And Raw materials
Raw materialsPotassium borohydride-->Maleic acid-->Ammonium carbonate
1-Dimethylamino-2-phenylbutan-2-yl 3,4,5-trimethoxybenzoate DESMETHYL TRIMEBUTINE HCL Methyl syringate Methyl 4,5-dimethoxy-3-hydroxybenzoate 2-Phenylpropyl acetate ISOBUTYL GALLATE Propyl gallate BUTYL GALLATE Isobutylparaben Syringic acid Trimebutine maleate Ethyl 3,4,5-trimethoxybenzoate 3,4,5-TRIMETHOXYLBENZOIC ACID (FOR TRIMEBUTINE MALEATE ) 3-Hydroxy-4,5-dimethoxybenzoic acid Vanillyl butyl ether Methyl 3,5-dihydroxybenzoate ETHYL 3,5-DIMETHOXYBENZOATE 2-DIMETHYLAMINO-2-METHYL-1-PROPANOL
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