2-Methylpiperazine

2-Methylpiperazine Basic information

Product Name:	2-Methylpiperazine
Synonyms:	2-methyl-piperazin;MP;2-METHYLDIETHYLENEDIAMINE;(+/-)-2-METHYLPIPERAZINE;2-METHYLPIPERAZINE;2MPRZ;2-METHYLPIPERAZINE/LOMEFLOXCIN;2-Methylpiperazine ,99%
CAS:	109-07-9
MF:	C5H12N2
MW:	100.16
EINECS:	203-644-2
Product Categories:	Building Blocks;C4 to C8;Building Blocks;Heterocyclic Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines, Piperidones, Piperazines;Piperaizine;Piperazine derivates;Piperazines
Mol File:	109-07-9.mol

2-Methylpiperazine Chemical Properties

Melting point	61-63 °C (lit.)
Boiling point	155 °C/763 mmHg (lit.)
density	0.817 g/cm
refractive index	1.4378 (estimate)
Fp	149 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	435g/l
pka	pK1:5.62(+2);pK2:9.60(+1) (25°C)
form	Crystalline Powder, Crystals and/or Chunks
color	White to yellow
PH	11-12 (50g/l, H2O)
Water Solubility	78 g/100 mL (25 ºC)
Sensitive	Air Sensitive & Hygroscopic
BRN	383566
InChIKey	JOMNTHCQHJPVAZ-UHFFFAOYSA-N
CAS DataBase Reference	109-07-9(CAS DataBase Reference)
NIST Chemistry Reference	Piperazine, 2-methyl-(109-07-9)
EPA Substance Registry System	Piperazine, 2-methyl- (109-07-9)

Safety Information

Hazard Codes	F,Xi
Risk Statements	11-36/37/38
Safety Statements	16-26-36/37/39-36
RIDADR	UN 1325 4.1/PG 2
WGK Germany	2
RTECS	TM1225020
F	10
TSCA	Yes
HazardClass	4.1
PackingGroup	III
HS Code	29339900

MSDS Information

Provider	Language
2-Methylpiperazine	English
SigmaAldrich	English
ACROS	English
ALFA	English

2-Methylpiperazine Usage And Synthesis

Chemical Properties	white to yellow crystalline powder and chunks
Uses	2-Methylpiperazine is used as a reagent in the design, synthesis and biological evaluation of diaminoquinazolines as b-catenine/Tcell transcription factor 4 (Tcf4) pathway inhibitor.
Purification Methods	Purify it by zone melting and by distillation. It is hygroscopic. The picrate has m 275-276o. [Beilstein 23 II 16, 23 III/IV 393, 23/3 V 267.]

2-Methylpiperazine Preparation Products And Raw materials

Raw materials	Ethylenediamine-->Propylene oxide-->3-Methyl-1-benzyl-piperazine-->2,5-Dimethylpiperazine-->2,6-Dimethylpiperazine-->D(+)-Glucose
Preparation Products	Lomefloxacin-->4-N-Boc-2-Methyl-piperazine-->Lomefloxacin hydrochloride-->TEMAFLOXACIN-->2-Methylpyrazine-->1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid-->(R)-(-)-2-Methylpiperazine-->DL-Alaninol-->1,2-DIMETHYL-PIPERAZINE-->Piperazine

CYCLO(-GLY-PRO) Piperacillin 2,6-Dimethylpiperazine Levodropropizine N-Aminoethylpiperazine 1-(3-METHOXYPHENYL)-2-METHYLPIPERAZINE 1,4-BIS(2-HYDROXYPROPYL)-2-METHYLPIPERAZINE (+/-)-1-(5-ISOQUINOLINESULPHONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE,(+/-)-1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE DIHYDROCHLORIDE 1-METHYLPIPERAZINE CYCLO(-PHE-SER) 2-Methylpiperazine Piperazine DL-2-AMINOPROPIONIC ANHYDRIDE 1,2,4-TRIMETHYLDIETHYLENEDIAMINE 1-(4-METHOXYPHENYL)-2-METHYLPIPERAZINE, 1:1 MIXTURE OF CONFORMERS, 95 CYCLO(-PHE-PRO) 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE 2-BROMOMETHYL-1,4-BENZODIOXANE

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