ChemicalBook Product Catalog Chemical Reagents Organic reagents Acyl halide 4-Bromobenzoyl chloride

4-Bromobenzoyl chloride

4-Bromobenzoyl chloride Basic information
Product Name:4-Bromobenzoyl chloride
Synonyms:4-BroMobenzoyl Chloride, 97+%;The broMine benzoyl chloride;4-BROMOBENZOYL CHLORIDE;AKOS BBS-00003926;4-Brorobenzoylchloride;4-Bromobenzoyl chlor;Of broMine chloride;4-Bromo-1-benzenecarbonyl chloride
CAS:586-75-4
MF:C7H4BrClO
MW:219.46
EINECS:209-580-1
Product Categories:Acid Halides;Carbonyl Compounds;Organic Building Blocks;Absolute Configuration Determination (Exciton Chirality CD Method);Analytical Chemistry;Enantiomer Excess & Absolute Configuration Determination;Exciton Chirality CD Method (for Hydroxyl Groups);Aromatic Halides (substituted);Pyridines ,Halogenated Heterocycles
Mol File:586-75-4.mol
4-Bromobenzoyl chloride Structure
4-Bromobenzoyl chloride Chemical Properties
Melting point 36-39 °C(lit.)
Boiling point 246 °C
density 1.6111 (rough estimate)
refractive index 1.5963 (estimate)
Fp >230 °F
storage temp. 2-8°C
solubility Chloroform, Methanol (Slightly)
form Low Melting Solid
color White to light brown
Water Solubility Soluble in methanol. Reacts with water forming Hcl.
Sensitive Moisture Sensitive
BRN 636641
Stability:Moisture Sensitive
CAS DataBase Reference586-75-4(CAS DataBase Reference)
NIST Chemistry ReferenceBenzoyl chloride, 4-bromo-(586-75-4)
EPA Substance Registry SystemBenzoyl chloride, 4-bromo- (586-75-4)
Safety Information
Hazard Codes C
Risk Statements 34-37
Safety Statements 26-36/37/39-45
RIDADR UN 3261 8/PG 2
WGK Germany 3
F 19-21
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29163900
MSDS Information
ProviderLanguage
4-Bromobenzoyl chloride English
SigmaAldrich English
ACROS English
ALFA English
4-Bromobenzoyl chloride Usage And Synthesis
Chemical PropertiesWhite to light brown low melting solid
Uses4-Bromobenzoyl chloride is used in the synthesis of HIV-1 protease inhibitors. It is also used in the synthesis of oxazoles, cyclohexanone derivatives as analgesic and antimicrobial agents.
Purification MethodsCheck IR of a film to see if OH bands are present. If absent then recrystallise from pet ether and dry it in vacuo. If OH bands are weak, then distil it in vacuo and recrystallise if necessary. If OH bands are very strong, then treat with an equal volume of redistilled SOCl2 reflux for 2hours, then evaporate excess of SOCl2 and distil the residual oil or low melting solid. Store it in the dark away from moisture. LACHRYMATORY. [Martin & Partington J Chem Soc 1175 1936, Beilstein 9 IV 1023.]
4-Bromobenzoyl chloride Preparation Products And Raw materials
Preparation Products2-(4-BROMOPHENYL)-5-(1-NAPHTHYL)-1,3,4-OXADIAZOLE-->2-(4-BROMOPHENYL)-5-PHENYL-1,3,4-OXADIAZOLE-->4-BROMO-4'-METHOXYBENZOPHENONE-->2-(4-BROMO-PHENYL)-1H-IMIDAZOLE-->1-(4-bromophenyl)-2-chloroethan-1-one-->3-(4-BROMO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER-->4-BROMO-3'-CHLOROBENZOPHENONE-->Methanone, (4-bromophenyl)-1H-indol-3-yl--->4-bromo-N-(6-methylpyridin-2-yl)benzamide-->4-BroMo-N,N-dicyclohexylbenzaMide, 97%-->N-(2-aminoethyl)-4-bromobenzamide-->4-bromo-N-(3,4-dimethoxyphenyl)benzamide
4-BROMO-4'-N-PENTYLBIPHENYL 4-(BROMOMETHYL)-BENZOIC ACID, 1,1-DIMETHYLETHYL ESTER 4-Bromobenzoic acid 4-Nitrobenzoyl chloride 2-Fluorobenzoyl chloride 4-BROMO-3,5-DIMETHOXYBENZOYL CHLORIDE 4-BROMO-2-CHLORO-5-FLUOROBENZOYL CHLORIDE 4-tert-Butylbenzoyl chloride o-Toluoyl chloride Ferric chloride 4-Bromobenzoyl chloride phenylhydrazone 4-BROMO-2,6-DIFLUOROBENZOYL CHLORIDE 4-Bromobenzenesulfonyl chloride 4-Chlorobenzoyl chloride 2-(benzyloxy)-5-bromobenzoyl chloride 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile 2,4-DIBROMO-6-FLUOROBENZOYL CHLORIDE p-Toluoyl chloride
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