ALLOBARBITAL

ALLOBARBITAL Basic information
Product Name:ALLOBARBITAL
Synonyms:ALLOBARBITAL;5,5-DIALLYLBARBITURIC ACID;2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-di-2-propenyl-;5,5-Di-2-propenyl-2,4,6(1H,3H,5H)-pyrimidinetrione;5,5-Diallyl-2,4,6(1H,3H,5H)-pyrimidinetrione;5,5-diallyl-barbituricaci;6(1h,3h,5h)-pyrimidinetrione,5,5-di-2-propenyl-4;Allbarbital
CAS:52-43-7
MF:C10H12N2O3
MW:208.21
EINECS:200-140-4
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
Mol File:52-43-7.mol
ALLOBARBITAL Structure
ALLOBARBITAL Chemical Properties
Melting point 171-173°
Boiling point 347.41°C (rough estimate)
density 1.2420 (rough estimate)
refractive index 1.4830 (estimate)
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka7.67±0.10(Predicted)
color White to Orange
Water Solubility 1.77g/L(25 ºC)
EPA Substance Registry System2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-di-2-propen-1-yl- (52-43-7)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS CQ3325000
HazardClass 6.1(b)
PackingGroup III
ToxicityLD50 i.p. in rats: 127.3 mg/kg (Sandberg)
MSDS Information
ProviderLanguage
SigmaAldrich English
ALLOBARBITAL Usage And Synthesis
OriginatorAllobarbital, Fluorochem Ltd.
UsesAllobarbital is a barbiturate derivative that is primarily used as an anticonvulsant. Allobarbital also shows hypnotic activity and is used to boost the activity of analgesic drugs. Studies show that Allobarbital is an effective promoters of hepatocarcinogenesis. Allobarbital is a Controlled Substance.
DefinitionChEBI: Allobarbital is a member of barbiturates.
Manufacturing ProcessTo a mixture of 43 parts barbituric acid, 200 parts of water and 5 parts of cuprous sulfate in 10 parts of water is added 82 parts of allylbromide. Then at room temperature is added 27 parts of sodium hydroxide (10% aqueous solution). 5,5-Diallylbarbituric acid is isolated by filtration. After recrystallization from water 5,5-diallylbarbituric acid has melting polint 169- 170°C.
Therapeutic FunctionSedative, Hypnotic
ALLOBARBITAL Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Allyl bromide-->Barbituric acid
Gabapentin Barbituric acid Allobarbital epoxide CYCLOPENTOBARBITAL brallobarbital ALLOBARBITAL ALLOBARBITAL [CONTROLLED SUBSTANCE] Allobarbital sodium BARBITAL Salsocain 1,5,5-triallylbarbituric acid

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