2-Chloro-5-fluoropyrimidine

2-Chloro-5-fluoropyrimidine Basic information

Product Name:	2-Chloro-5-fluoropyrimidine
Synonyms:	Pyrimidine, 2-chloro-5-fluoro- (9CI);2-CHLORO-5-FLUOROPYRIMIDINE;Pyrimidine,2-chloro-5-fluoro-;2-Chloro-5-fluoropyr;2-Chloro-5-fluoropyriMidi...;2-Chloro-5-fluoropyrimidine ,98%;2-Chloro-5-fluoro-1,3-diazine;2-Chloro-5-fluoropyrimidine >
CAS:	62802-42-0
MF:	C4H2ClFN2
MW:	132.52
EINECS:
Product Categories:	Fluorine series;Bases & Related Reagents;Nucleotides;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;PYRIMIDINE;Pyrimidine series;pharmacetical;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Variety of halogenated heterocyclic series;62802-42-0
Mol File:	62802-42-0.mol

2-Chloro-5-fluoropyrimidine Chemical Properties

Boiling point	149.0-162.0°C
density	1.439 g/mL at 20 °C (lit.)
refractive index	n20/D 1.503(lit.)
Fp	150 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	Liquid
pka	-2.54±0.22(Predicted)
color	Clear colorless to yellow
InChI	InChI=1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
InChIKey	AGYUQBNABXVWMS-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(F)C=N1
CAS DataBase Reference	62802-42-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-34-41-37/38
Safety Statements	26-36/37/39-45
RIDADR	UN 2735 8/PG 2
WGK Germany	3
Hazard Note	Harmful
HazardClass	IRRITANT
HazardClass	8
PackingGroup	Ⅲ
HS Code	29335990

MSDS Information

Provider	Language
SigmaAldrich	English

2-Chloro-5-fluoropyrimidine Usage And Synthesis

Chemical Properties	Colorless to light yellow liquid
Uses	2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.
Uses	2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of: 5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction. 2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors. 5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.
Preparation	Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.

2-Chloro-5-fluoropyrimidine Preparation Products And Raw materials

(2Z)-2-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]BENZYLIDENE}[1,3]THIAZOLO[3,2-A]BENZIMIDAZOL-3(2H)-ONE Cyhalothrin 2-[(2-chloro-5-fluoro-4-pyrimidinyl)amino]ethanol CHEMBRDG-BB 6873131 (2Z)-3-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]PHENYL}-2-CYANO-N-(2,4-DIMETHYLPHENYL)ACRYLAMIDE (2Z)-3-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]PHENYL}-2-(MORPHOLIN-4-YLCARBONYL)ACRYLONITRILE 2,4-Dichloro-5-fluoropyrimidine 3-[(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)OXY]-4-METHOXYBENZALDEHYDE CHEMBRDG-BB 4015094 2-CHLORO-5-FLUOROPYRIMIDIN-4-ONE 2-Chloro-5-fluoropyrimidine {4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]-3-METHOXYBENZYLIDENE}MALONONITRILE N-ALLYL-N-(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)AMINE 4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE,4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE GC 95.0%,2-Chloro-5-fluoropyrimidine-4-amine 4-[(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)OXY]BENZALDEHYDE 5-{4-[(2-CHLORO-5-FLUOROPYRIMIDIN-4-YL)OXY]-3-ETHOXYBENZYLIDENE}-2-THIOXODIHYDROPYRIMIDINE-4,6(1H,5H)-DIONE 2-CHLORO-4-(DIMETHYLAMINO)-5-FLUOROPYRIMIDINE N-(2-CHLORO-5-FLUORO-4-PYRIMIDINYL)-N-(2,3-DIMETHYLPHENYL)AMINE

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